Comprehensive preclinical evaluation of a multi-physics model of liver tumor radiofrequency ablation

  • Chloé AudigierEmail author
  • Tommaso Mansi
  • Hervé Delingette
  • Saikiran Rapaka
  • Tiziano Passerini
  • Viorel Mihalef
  • Marie-Pierre Jolly
  • Raoul Pop
  • Michele Diana
  • Luc Soler
  • Ali Kamen
  • Dorin Comaniciu
  • Nicholas Ayache
Original Article



We aim at developing a framework for the validation of a subject-specific multi-physics model of liver tumor radiofrequency ablation (RFA).


The RFA computation becomes subject specific after several levels of personalization: geometrical and biophysical (hemodynamics, heat transfer and an extended cellular necrosis model). We present a comprehensive experimental setup combining multimodal, pre- and postoperative anatomical and functional images, as well as the interventional monitoring of intra-operative signals: the temperature and delivered power.


To exploit this dataset, an efficient processing pipeline is introduced, which copes with image noise, variable resolution and anisotropy. The validation study includes twelve ablations from five healthy pig livers: a mean point-to-mesh error between predicted and actual ablation extent of 5.3 ± 3.6 mm is achieved.


This enables an end-to-end preclinical validation framework that considers the available dataset.


Computational modeling Radiofrequency ablation Preclinical evaluation 



Part of this work was funded by Inria, Siemens Healthcare, IHU Strasbourg (SimulAB project) and by the European Research Council (ERC Advanced Grant MedYMA 2011-291080). The authors are grateful to Gael Fourré, Franck Blindauer, Mourad Bouhadjar and Rodrigo Cararo at the IHU Strasbourg for their valuable assistance in performing the experimental procedures.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

Informed consent

This articles does not contain patient data.

Supplementary material

11548_2016_1517_MOESM1_ESM.pdf (888 kb)
Supplementary material 1 (pdf 888 KB)


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Copyright information

© CARS 2017

Authors and Affiliations

  • Chloé Audigier
    • 1
    • 2
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  • Tommaso Mansi
    • 2
  • Hervé Delingette
    • 1
  • Saikiran Rapaka
    • 2
  • Tiziano Passerini
    • 2
  • Viorel Mihalef
    • 2
  • Marie-Pierre Jolly
    • 2
  • Raoul Pop
    • 3
  • Michele Diana
    • 3
  • Luc Soler
    • 3
    • 4
  • Ali Kamen
    • 2
  • Dorin Comaniciu
    • 2
  • Nicholas Ayache
    • 1
  1. 1.Université Côte d’Azur and Inria Sophia-Antipolis Méditerranée Asclepios teamInria Sophia AntipolisFrance
  2. 2.Medical Imaging Technologies, Siemens HealthcarePrincetonUSA
  3. 3.IHU - Institut de Chirugie Guidée Par L’ImageStrasbourgFrance
  4. 4.IRCAD - Institut de Recherche Contre Les Cancers de L’Appareil DigestifStrasbourgFrance

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