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Three-dimensional quantitative assessment of ablation margins based on registration of pre- and post-procedural MRI and distance map

  • Soichiro Tani
  • Servet Tatli
  • Nobuhiko Hata
  • Xavier Garcia-Rojas
  • Olutayo I. Olubiyi
  • Stuart G. Silverman
  • Junichi Tokuda
Original Article

Abstract

Purpose

Contrast-enhanced MR images are widely used to confirm the adequacy of ablation margin after liver ablation for early prediction of local recurrence. However, quantitative assessment of the ablation margin by comparing pre- and post-procedural images remains challenging. We developed and tested a novel method for three-dimensional quantitative assessment of ablation margin based on non-rigid image registration and 3D distance map.

Methods

Our method was tested with pre- and post-procedural MR images acquired in 21 patients who underwent image-guided percutaneous liver ablation. The two images were co-registered using non-rigid intensity-based registration. After the tumor and ablation volumes were segmented, target volume coverage, percent of tumor coverage, and Dice similarity coefficient were calculated as metrics representing overall adequacy of ablation. In addition, 3D distance map around the tumor was computed and superimposed on the ablation volume to identify the area with insufficient margins. For patients with local recurrences, the follow-up images were registered to the post-procedural image. Three-dimensional minimum distance between the recurrence and the areas with insufficient margins was quantified.

Results

The percent tumor coverage for all nonrecurrent cases was 100 %. Five cases had tumor recurrences, and the 3D distance map revealed insufficient tumor coverage or a 0-mm margin. It also showed that two recurrences were remote to the insufficient margin.

Conclusions

Non-rigid registration and 3D distance map allow us to quantitatively evaluate the adequacy of the ablation margin after percutaneous liver ablation. The method may be useful to predict local recurrences immediately following ablation procedure.

Keywords

Liver ablation MRI Image-guided intervention  Ablation margin Image registration 

Notes

Acknowledgments

The authors would like to thank Vincent M. Levesque for his assistance in collecting patient data.

Funding This study was supported by the National Institutes of Health (R01CA138586, R01EB020667, P41EB015898). S.Tani received funds from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. The content of the material is solely the responsibility of the authors and does not necessarily represent the official views of these agencies.

Compliance with ethical standards

Ethical standards

The study protocol has been reviewed and approved by the institutional review board at Brigham and Women’s Hospital (IRB# 2002P001166), and was HIPAA compliant. Informed consent was waived by our institutional review board. NH has a financial interest in Harmonus, a company developing image-guided therapy products. NH’s interests were reviewed and are managed by Brigham and Women’s Hospital and Partners HealthCare in accordance with their conflict of interest policies.

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Copyright information

© CARS 2016

Authors and Affiliations

  • Soichiro Tani
    • 1
    • 2
  • Servet Tatli
    • 1
  • Nobuhiko Hata
    • 1
  • Xavier Garcia-Rojas
    • 3
  • Olutayo I. Olubiyi
    • 1
  • Stuart G. Silverman
    • 1
  • Junichi Tokuda
    • 1
  1. 1.Department of RadiologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Department of Surgery, Biomedical Innovation CenterShiga University of Medical ScienceOtsuJapan
  3. 3.Texas Medical CenterHoustonUSA

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