Disc herniation diagnosis in MRI using a CAD framework and a two-level classifier
Abstract
Purpose
Disc herniation in the lumbar spine is a common condition, so an automated method for diagnosis could be helpful in clinical applications. A computer-aided framework for disk herniation diagnosis was developed for use in magnetic resonance imaging (MRI).
Materials and Method
A computer-aided diagnosis framework for lumbar spine with a two-level classification scheme for disc herniation diagnosis was developed using heterogeneous classifiers: a perceptron classifier, a least mean square classifier, a support vector machine classifier, and a k-Means classifier. Each classifier makes a diagnosis based on a feature set generated from regions of interest that contain vertebrae, a disc, and the spinal cord. Then, an ensemble classifier makes a final decision using score values of each classifier. We used clinical MR image data from 70 subjects in T1-weighted sagittal view and T2-weighted sagittal view for evaluation of the system.
Results
MR images of 70 subjects were processed using the proposed framework resulting in successful detection of disc herniation with 99% accuracy, achieving a speedup factor of 30 in comparison with radiologist’s diagnosis.
Conclusion
The computer-aided framework works well to diagnose herniated discs in MRI scans. We expect the framework can be adapted to effectively diagnose a variety of abnormalities in the lumbar spine.
Keywords
Lower back pain Computer-aided diagnosis Classifier Disc herniation Lumbar spine MRIPreview
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References
- 1.Freymoyer JW (1999) Back pain and sciatica. N Engl J Med 318: 291–300CrossRefGoogle Scholar
- 2.Brant-Zawadzki MN, Dennis SC, Gade GF, Weinstein MP (2000) Low back pain. Radiology 217: 321–330PubMedGoogle Scholar
- 3.Deyo RA, Mirza S, Martin BI (2002) Back pain prevalence and visit rates: estimates from US national surveys. Spine 31: 2724–2727CrossRefGoogle Scholar
- 4.Cherry DK, Hing E, Woodwell DA, Rechtsteiner EA (2008) National Ambulatory Medical Care Survey: 2006 Summary. Natl Health Stat Report 3: 1–39PubMedGoogle Scholar
- 5.Beattie PF, Meyers SP (1998) Magnetic resonance imaging in low back pain: general principles and clinical issues. Phys Ther 78: 738–753PubMedGoogle Scholar
- 6.Sheehan NJ (2010) Magnetic resonance imaging for low back pain: indications and limitations. ARD 69: 7–11PubMedGoogle Scholar
- 7.Bhargavan M, Kaye AH, Forman HP, Sunshine JH (2009) Workload of radiologists in United States in 2006–2007 and trends since 1991–1992. Radiology 252(2): 458–467PubMedCrossRefGoogle Scholar
- 8.Fardon DF, Milette PC (2001) Nomenclature and classification of lumbar disc pathology. Spine 26: E93–E113PubMedCrossRefGoogle Scholar
- 9.Kim KY, Kim YT, Lee CS, Kang JS, Kim YJ (1993) Magnetic resonance imaging in the evaluation of the lumbar herniated intervertebral disc. Int Orthop 17: 241–244PubMedGoogle Scholar
- 10.Chwialkowski MP, Shile PE, Peshock RM, Pfeifer D, Parkey RW (1989) Automated detection and evaluation of lumbar discs in MR images. IEEE Eng Med Biol 2: 571–572Google Scholar
- 11.Milette PC (2000) Classification, diagnostic imaging, and imaging characterization of a lumbar herniated disk. Radiol Clin North Am 38: 1267–1292PubMedCrossRefGoogle Scholar
- 12.Pfirrmann CWA, Metzdorf A, Zanetti JHM, Boos N (2001) Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 26: 1873–1878PubMedCrossRefGoogle Scholar
- 13.Thalgott JS, Albert TJ, Vaccaro AR, Aprill CN, Giuffre JM, Drake JS, Henke JP (2004) A new classification system for degenerative disc disease of the lumbar spine based on magnetic resonance imaging, provocative discography, plain radiographs and anatomic considerations. Spine 4: 167S–172SCrossRefGoogle Scholar
- 14.Griffith JF, Wang Y-XJ, Antonio GE, Choi KC, Yu A, Jhuja AT, Leung PC (2007) Modified pfirrmann grading system for lumbar intervertebral disc degeneration. Spine 32: E708–E712PubMedCrossRefGoogle Scholar
- 15.Jarvik JG, Deyo RA (2002) Diagnostic evaluation of low back pain with emphasis on imaging. Ann Intern Med 137: 586–597PubMedGoogle Scholar
- 16.Graaf I, Prak A, Bierma-Seinstra S, Thomas S, Peul W, Koes B (2006) Diagnosis of lumbar spinal stenosis: a systematic review of the accuracy of diagnostic tests. Spine 31: 1168–1176PubMedCrossRefGoogle Scholar
- 17.Koh J, Chaudhary V, Dhillon G (2010) Diagnosis of disc herniation based on classifiers and features generated from spine MR images. Proc SPIE 7624: 76243OCrossRefGoogle Scholar
- 18.Koh J, Chaudhary V, Dhillon G (2010) A fully automated method of associating axial slices with a disc based on labeling of multi-protocol lumbar MRI. International Conference on Image Processing, pp 4341–4344. doi: 10.1109/ICIP.2010.5652393
- 19.Koh J, Alomari RS, Chaudhary V, Dhillon G (2011) Lumbar spinal stenosis CAD from clinical MRM and MRI based on inter- and intra-context features with a two-level classifier. Proc SPIE 7963: 796304CrossRefGoogle Scholar
- 20.Koh J, Scott PD, Chaudhary V, Dhillon G (2011) An automated segmentation method of the spinal canal from clinical MR images based on an attention model and an active contour model. IEEE International Symposium on Biomedical Imaging, pp 1467–1471. doi: 10.1109/ISBI.2011.5872677
- 21.Bhole C, Kompalli S, Chaudhary V (2009) Context-sensitive labeling of spinal structures in MRI images. Proc SPIE 7260: 72603PCrossRefGoogle Scholar
- 22.Koh J, Kim T, Chaudhary V, Dhillon G (2010) Automatic segmentation of the spinal cord and the dural sac in lumbar MR images using gradient vector flow field. In: Data mining: practical machine learning tools and techniques, 3rd edn. International Conference on IEEE Engineering in Medicine and Biology Society, pp 2117–2120Google Scholar
- 23.Witten IH, Frank E, Hall MA (2011) Data mining: practical machine learning tools and techniques, 3rd edn. Morgan Kaufmann, BurlingtonGoogle Scholar