Fetal brain volumetry through MRI volumetric reconstruction and segmentation
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Fetal MRI volumetry is a useful technique but it is limited by a dependency upon motion-free scans, tedious manual segmentation, and spatial inaccuracy due to thick-slice scans. An image processing pipeline that addresses these limitations was developed and tested.
Materials and methods
The principal sequences acquired in fetal MRI clinical practice are multiple orthogonal single-shot fast spin echo scans. State-of-the-art image processing techniques were used for inter-slice motion correction and super-resolution reconstruction of high-resolution volumetric images from these scans. The reconstructed volume images were processed with intensity non-uniformity correction and the fetal brain extracted by using supervised automated segmentation.
Reconstruction, segmentation and volumetry of the fetal brains for a cohort of twenty-five clinically acquired fetal MRI scans was done. Performance metrics for volume reconstruction, segmentation and volumetry were determined by comparing to manual tracings in five randomly chosen cases. Finally, analysis of the fetal brain and parenchymal volumes was performed based on the gestational age of the fetuses.
The image processing pipeline developed in this study enables volume rendering and accurate fetal brain volumetry by addressing the limitations of current volumetry techniques, which include dependency on motion-free scans, manual segmentation, and inaccurate thick-slice interpolation.
KeywordsFetal MRI Brain volumetry Image reconstruction Segmentation
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- 17.Gholipour A, Warfield SK (2009) Super-resolution reconstruction of fetal brain MRI. In: Studholme C, Rousseau F (eds) MICCAI Workshop on Image Analysis for the Developing Brain (IADB’2009). London, UK, pp 45–52, 24 Sept 2009 [Online]. Available: http://www.crl.med.harvard.edu/publications/SR-Fetal-Brain-MRI-IADB-MICCAI2009.pdf
- 18.Gholipour A Estroff JA, Warfield SK (2010) Robust super-resolution volume reconstruction from slice acquisitions: application to fetal brain MRI. IEEE Trans Med Imaging. doi: 10.1109/TMI.2010.2051680 (in press)
- 23.Kim K, Habas PA, Rousseau F, Glenn OA, Barkovich AJ, Studholme C (2010) Intersection based motion correction of multislice MRI for 3D in utero fetal brain image formation. IEEE Trans Med Imag 29(1):146–158Google Scholar
- 25.Mangin J (2000) Entropy minimization for automatic correction of intensity nonuniformity. In: Proceedings of the of the IEEE workshop on mathematical methods in biomedical image analysis. p 162Google Scholar
- 28.Liao P, Chen T, Chung P (2001) A fast algorithm for multilevel thresholding. J Inf Sci Eng 17(5): 713–727Google Scholar
- 30.Sethian JA (1999) Level set methods and fast marching methods: evolving interfaces in computational geometry, fluid mechanics, computer vision, and materials science. Cambridge University Press. ISBN 0-521-64557-3Google Scholar