Hybrid 3D pregnant woman and fetus modeling from medical imaging for dosimetry studies
- 178 Downloads
Numerical simulations studying the interactions between radiations and biological tissues require the use of three-dimensional models of the human anatomy at various ages and in various positions. Several detailed and flexible models exist for adults and children and have been extensively used for dosimetry. On the other hand, progress of simulation studies focusing on pregnant women and the fetus have been limited by the fact that only a small number of models exist with rather coarse anatomical details and a poor representation of the anatomical variability of the fetus shape and its position over the entire gestation.
In this paper, we propose a new computational framework to generate 3D hybrid models of pregnant women, composed of fetus shapes segmented from medical images and a generic maternal body envelope representing a synthetic woman scaled to the dimension of the uterus. The computational framework includes the following tasks: image segmentation, contour regularization, mesh-based surface reconstruction, and model integration.
A series of models was created to represent pregnant women at different gestational stages and with the fetus in different positions, all including detailed tissues of the fetus and the utero-fetal unit, which play an important role in dosimetry. These models were anatomically validated by clinical obstetricians and radiologists who verified the accuracy and representativeness of the anatomical details, and the positioning of the fetus inside the maternal body.
The computational framework enables the creation of detailed, realistic, and representative fetus models from medical images, directly exploitable for dosimetry simulations.
Keywords3D Modeling Segmentation Fetus Ultrasound MRI Dosimetry
- 2.Burguet J, Bloch I (2004) Homotopic labeling of elements in a tetrahedral mesh for the head modeling. In: Progress in pattern recognition, image analysis and applications, LNCS, vol 3287. Puebla, Mexico, pp 566–573Google Scholar
- 3.Burguet J, Gadi N, Bloch I (2004) Realistic models of children heads from 3D MRI segmentation and tetrahedral mesh construction. In: 2nd International symposium on 3D data processing, visualization and transmission, 3DPTV. Thessaloniki, Greece, pp 631–638Google Scholar
- 5.Stabin MG et al (1995) Mathematical models and specific absorbed fractions of photon energy in the nonpregnant adult females and at the end of each trimester of pregnancy. Oak Ridge National Laboratory; National Technical Information Service, SpringfieldGoogle Scholar
- 16.Anquez J, Angelini E, Bloch I, Merzoug V, Bellaiche-Millischer AE, Adamsbaum C (2007) Interest of the steady state free precession (SSFP) sequence for 3D modeling of the whole fetus. In: International conference of the IEEE engineering in medicine and biology society. Lyon, France, pp 771–774Google Scholar
- 17.Anquez J, Angelini E, Bloch I (2008) Segmentation of fetal 3D ultrasound images based on statistical prior and deformable model. In: IEEE international symposium on biomedical imaging (ISBI). Paris, France, pp 17–20Google Scholar
- 18.Anquez J, Angelini E, Bloch I (2009) Automatic segmentation of head structures on fetal MRI. In: IEEE international symposium on biomedical imaging (ISBI). Boston, USAGoogle Scholar
- 19.Anquez J, Boubekeur T, Bibin L, Angelini E, Bloch I (2009) Utero-fetal unit and pregnant woman modeling using a computer graphics approach for dosimetry studies. In: Medical image computing and computerized assisted intervertion, London, UKGoogle Scholar
- 20.Moore KL, Persaud TVN (1993) The developing human: clinically oriented embryology. WB Saunders Company, PhiladelphiaGoogle Scholar
- 21.Bibin L, Anquez J, Hadjem A, Angelini E, Wiart J, Bloch I (2009) Dosimetry studies on a fetus model combining medical image information and synthetic woman body. In: 11th World congress on medical physics and biomedical engineering. Munich, GermanyGoogle Scholar