La radiologia medica

, Volume 124, Issue 11, pp 1121–1127 | Cite as

New advances in MRI diagnosis of degenerative osteoarthropathy of the peripheral joints

  • Federico Bruno
  • Francesco Arrigoni
  • Pierpaolo Palumbo
  • Raffaele Natella
  • Nicola Maggialetti
  • Alfonso Reginelli
  • Alessandra Splendiani
  • Ernesto Di Cesare
  • Luca Brunese
  • Giuseppe Guglielmi
  • Andrea Giovagnoni
  • Carlo Masciocchi
  • Antonio BarileEmail author


Degenerative osteoarthropathy is one of the leading causes of the pain and disability from musculoskeletal disease in the adult population. Magnetic resonance imaging (MRI) allows optimal visualization of all tissues involved in degenerative osteoarthritis disease process, mainly the articular cartilage. In addition to qualitative and semiquantitative morphologic assessment, several MRI-based advanced techniques have been developed to allow characterization and quantification of the biochemical cartilage composition. These include quantitative analysis and several compositional techniques (T1 and T2 relaxometry measurements and mapping, sodium imaging, delayed gadolinium-enhanced MRI of cartilage dGEMRIC, glycosaminoglycan-specific chemical exchange saturation transfer gagCEST, diffusion-weighted imaging DWI and diffusion tensor imaging DTI). These compositional MRI techniques may have the potential to serve as quantitative, reproducible, noninvasive and objective endpoints for OA assessment, particularly in diagnosis of early and pre-radiographic stages of the disease and in monitoring disease progression and treatment effects over time.


MRI Cartilage Advanced imaging T2 mapping DWI 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

This article does not contain any studies with human participants performed by any of the authors.


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Copyright information

© Italian Society of Medical Radiology 2019

Authors and Affiliations

  • Federico Bruno
    • 1
  • Francesco Arrigoni
    • 1
  • Pierpaolo Palumbo
    • 1
  • Raffaele Natella
    • 2
  • Nicola Maggialetti
    • 3
  • Alfonso Reginelli
    • 2
  • Alessandra Splendiani
    • 1
  • Ernesto Di Cesare
    • 1
  • Luca Brunese
    • 3
  • Giuseppe Guglielmi
    • 4
  • Andrea Giovagnoni
    • 5
  • Carlo Masciocchi
    • 1
  • Antonio Barile
    • 1
    Email author
  1. 1.Department of Biotechnological and Applied Clinical SciencesUniversity of L’AquilaL’AquilaItaly
  2. 2.Department of Precision MedicineUniversity of Campania “Luigi Vanvitelli”NaplesItaly
  3. 3.Department Life and Health “V. Tiberio”University of MoliseCampobassoItaly
  4. 4.Department of Radiology, Scientific Institute “Casa Sollievo della Sofferenza” HospitalUniversity of FoggiaFoggiaItaly
  5. 5.Department of Radiology, Ospedali RiunitiUniversità Politecnica delle MarcheAnconaItaly

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