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Evaluation of CSF flow metrics in patients with communicating hydrocephalus and idiopathic intracranial hypertension

  • Temel Fatih Yılmaz
  • Ayse AralasmakEmail author
  • Huseyin Toprak
  • Elnur Mehdi
  • Gulsen Kocaman
  • Serpil Kurtcan
  • Mehmet Onur Kaya
  • Alpay Alkan
MAGNETIC RESONANCE IMAGING
  • 54 Downloads

Abstract

Purpose

To search for CSF dynamics of idiopathic intracranial hypertension (IIH) and communicating hydrocephalus and any correlation between MRI findings, CSF metrics and CSF opening pressure in IIH.

Materials and methods

Healthy subjects (30) and subjects with IIH (29) and high-pressure communicating hydrocephalus (43) were enrolled. Nonparametric Kruskal–Wallis test (p = 0.05) was used to compare three groups, Mann–Whitney U test with Bonferroni correction to compare two groups (p = 0.016). Correlation of MRI findings of IIH with CSF metrics and CSF opening pressure was analyzed by Spearman’s Rank correlation coefficient (p = 0.05).

Results

In IIH, no correlation between MRI findings and aqueductal stroke volume (ASV) but statistically significantly CSF opening pressure in the presence of transverse sinus compression was noted. Comparing with healthy subjects, ASV was nonsignificantly lower and standardized diastolic and sum and difference of systolic and diastolic flow durations were statistically significantly lower. Comparing with hydrocephalus, the width of prepontine cistern (PPC)/the width of aqueductus sylvii (AS) was significantly higher and other CSF metrics with standardized systolic and sum of systolic and diastolic flow durations were significantly lower. In hydrocephalus, ASV and peak velocities were significantly higher. Compared with normal group, PPC/AS and reverse/forward flow duration were significantly lower and other CSF metrics were significantly higher.

Conclusion

In hydrocephalus, significant increase in ASV and peak velocities were noted. In IIH, CSF opening pressure was statistically significantly high in the presence of transverse sinus compression and standardized diastolic flow durations were statistically significantly short that are probably effects of increased impedance of CSF flow against increased intracranial pressure and unchanged or even decreased intraventricular CSF volume.

Keywords

CSF flow Idiopathic intracranial intracranial hypertension Communicating hydrocephalus MRI findings 

Abbreviations

MRI

Magnetic resonance imaging

IIH

Idiopathic intracranial hypertension

CSF

Cerebrospinal fluid

ASV

Aqueductal stroke volume

PC-MRI

Phase contrast magnetic resonance imaging

PPC

Prepontine cistern

AS

Aqueductus sylvii

3D-SPACE

3D sampling perfection with application-optimized contrasts using different flip angle evolutions

3D-CISS

3D constructive interference in steady state

Notes

Authors’ contribution

TFY and HT contributed to data collection, data archiving, manuscript writing; AA was involved in project development, data collection, data archiving, manuscript writing; EM contributed to data collection, data archiving; GK, Neurologist, took care of the patients; SK and AA were involved in project development; MOK contributed to biostatistical analysis.

Compliance with ethical standards

Conflict of interest

The authors have declared no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Italian Society of Medical Radiology 2018

Authors and Affiliations

  1. 1.Department of RadiologyBezmialemVakif UniversityIstanbulTurkey
  2. 2.Department of NeurologyBezmialemVakif UniversityIstanbulTurkey
  3. 3.Department of BiostatisticsBezmialemVakif UniversityIstanbulTurkey

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