Shear wave elastography of parotid glands in pediatric patients with HIV infection
- 64 Downloads
Parotid gland (PG) involvement is common among the patients with HIV infection. Shear wave elastography (SWE) is a noninvasive method used to measure the tissue stiffness of several organs including PG. The aim of this study was to evaluate the tissue stiffness values of PGs of HIV-infected children via SWE and compare the results with the counterparts of healthy subjects.
Materials and methods
This single-center, prospective study included the PG examinations of 23 pediatric HIV patients and 40 healthy children via grayscale ultrasound and SWE. Independent sample T test and Mann–Whitney U test were used in statistical analysis.
Stiffness of both PGs was significantly higher in patients’ group when compared with control subjects. In addition, when the patients were separated into two groups according to the appearance of PG on grayscale ultrasound as homogeneous and heterogeneous, stiffness values were increased in the patients with homogeneous parenchymal appearance. No significant difference was achieved in terms of median CD4 and CD8 counts, HIV RNA levels or median duration of illnesses.
PG examination of HIV-infected children via SWE reveals increased tissue stiffness when compared with healthy subjects. SWE can be used as an ultrasound-assisted noninvasive technique in this manner.
KeywordsHuman immunodeficiency virus infection Parotid gland Shear wave elastography Children
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with animals performed by any of the authors.
Informed consent was obtained from all individuals and their legal guardians included in the study.
- 3.Williams MA (1987) Head and neck findings in pediatric acquired immune deficiency syndrome. Laryngoscope 97:713–716Google Scholar
- 7.De Cocker LJ, D’Arco F, De Beule T, Tousseyn T, Blockmans D, Hermans R (2014) IgG4-related systemic disease affecting the parotid and submandibular glands: magnetic resonance imaging features of IgG4-related chronic sclerosing sialadenitis and concomitant lymphadenitis. Clin Imaging 38:195–198CrossRefGoogle Scholar
- 8.Pirog SC, Agoff SN, Aboulafia DM (2007) Images in HIV/AIDS. Parotid gland enlargement and fat maldistribution syndrome in an HIV-infected man. AIDS Read 17:26–28Google Scholar