La radiologia medica

, Volume 124, Issue 2, pp 126–131 | Cite as

Shear wave elastography of parotid glands in pediatric patients with HIV infection

  • Manolya KaraEmail author
  • Emine Caliskan
  • Gurkan Atay
  • Murat Sutcu
  • Ozge Kaba
  • Ibrahim Adaletli
  • Selda Hancerli Torun
  • Ayper Somer



Parotid gland (PG) involvement is common among the patients with HIV infection. Shear wave elastography (SWE) is a noninvasive method used to measure the tissue stiffness of several organs including PG. The aim of this study was to evaluate the tissue stiffness values of PGs of HIV-infected children via SWE and compare the results with the counterparts of healthy subjects.

Materials and methods

This single-center, prospective study included the PG examinations of 23 pediatric HIV patients and 40 healthy children via grayscale ultrasound and SWE. Independent sample T test and Mann–Whitney U test were used in statistical analysis.


Stiffness of both PGs was significantly higher in patients’ group when compared with control subjects. In addition, when the patients were separated into two groups according to the appearance of PG on grayscale ultrasound as homogeneous and heterogeneous, stiffness values were increased in the patients with homogeneous parenchymal appearance. No significant difference was achieved in terms of median CD4 and CD8 counts, HIV RNA levels or median duration of illnesses.


PG examination of HIV-infected children via SWE reveals increased tissue stiffness when compared with healthy subjects. SWE can be used as an ultrasound-assisted noninvasive technique in this manner.


Human immunodeficiency virus infection Parotid gland Shear wave elastography Children 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individuals and their legal guardians included in the study.


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Copyright information

© Italian Society of Medical Radiology 2018

Authors and Affiliations

  1. 1.Department of Pediatric Infectious DiseasesIstanbul University Faculty of MedicineFatih, IstanbulTurkey
  2. 2.Department of Pediatric RadiologySeyhan State HospitalAdanaTurkey
  3. 3.Department of Pediatric Intensive CareIstanbul University Faculty of MedicineIstanbulTurkey
  4. 4.Department of Pediatric Infectious DiseasesKonya Training and Research HospitalKonyaTurkey
  5. 5.Department of Pediatric RadiologyIstanbul University Faculty of MedicineIstanbulTurkey

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