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La radiologia medica

, Volume 124, Issue 2, pp 87–93 | Cite as

The evaluation of prostate lesions with IVIM DWI and MR perfusion parameters at 3T MRI

  • Murat Beyhan
  • Recep Sade
  • Erdem Koc
  • Senol Adanur
  • Mecit KantarciEmail author
ABDOMINAL RADIOLOGY
  • 108 Downloads

Purpose

The purpose of our study was to analyze the difference between IVIM DWI and perfusion parameters of malignant lesions and benign lesions–normal prostate tissue.

Methods

This prospective study included 31 patients who had multiparametric prostate MRI with IVIM DWI due to elevated prostate-specific antigen level and clinical suspicion between February 2015 and September 2016.

Results

For peripheral zone, the mean values of Ktrans, Kep, iAUC, χ2 and f were significantly higher in malignant lesions, and the mean values of Dt were significantly lower in malignant lesions (p 0.00, p 0.02, p 0.00, p 0.02 and p 0.00, respectively). For transitional zone, the mean values of Ktrans, Ve, iAUC, χ2 and f were significantly higher in malignant lesions, and the mean values of Dp and Dt were significantly lower in malignant lesions (p 0.00, p 0.00, p 0.00, p 0.00, p 0.00, p 0.02 and p 0.00, respectively). For whole prostate gland, the mean values of Ktrans, Kep, Ve, iAUC, χ2 and f were significantly higher in malignant lesions, and the mean values of Dp and Dt were significantly lower in malignant lesions (p 0.00, p 0.03, p 0.00, p 0.00, p 0.00, p 0.01, p 0.04 and p 0.00, respectively).

Conclusions

Restricted diffusion–pseudodiffusion and increased perfusion parameters are important to differentiate prostate cancer from benign pathologies. It is also important to keep in mind that transitional zone and peripheral zone tumors may have different perfusion and diffusion parameters. Future studies are needed to confirm our findings.

Keywords

Prostate lesion Magnetic resonance imaging IVIM Perfusion 

Notes

Acknowledgements

We thank Henry Rusinek (PhD) for helping us to reach and use FireVoxel (IVIM-DWI evaluation program).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Italian Society of Medical Radiology 2018

Authors and Affiliations

  • Murat Beyhan
    • 1
  • Recep Sade
    • 2
  • Erdem Koc
    • 3
  • Senol Adanur
    • 4
  • Mecit Kantarci
    • 2
    Email author
  1. 1.Radiology ClinicTokat State HospitalTokatTurkey
  2. 2.Department of Radiology, School of MedicineAtaturk UniversityYakutiye, ErzurumTurkey
  3. 3.Department of Urology, School of MedicineYıldırım Beyazıt UniversityErzurumTurkey
  4. 4.School of Medicine, Department of UrologyAtaturk UniversityErzurumTurkey

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