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La radiologia medica

, Volume 122, Issue 1, pp 1–15 | Cite as

Diagnostic performance of computed tomography and magnetic resonance imaging for detecting peritoneal metastases: systematic review and meta-analysis

  • Andrea LaghiEmail author
  • Davide Bellini
  • Marco Rengo
  • Fabio Accarpio
  • Damiano Caruso
  • Daniele Biacchi
  • Angelo Di Giorgio
  • Paolo Sammartino
ABDOMINAL RADIOLOGY

Abstract

Purpose

Primary end point was to assess diagnostic accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) in detecting peritoneal metastases (PM). Secondary end points were determining the diagnostic sensitivity and specificity of CT in detecting PM according to the peritoneal cancer index (PCI), investigating correlations between radiological and surgical PCI, and comparing diagnostic yield of CT versus positron emission tomography (PET)/CT.

Materials and methods

We searched MEDLINE, Cochrane Library, Embase and Web of Science databases. Analytic methods were based on PRISMA. Pooled estimates for sensitivity, specificity, positive and negative likelihood ratios were calculated using fixed and random effect models. I 2 was used to evaluate heterogeneity.

Results

Of the 529 articles initially identified, 22 were selected for inclusion (934 patients). Cumulative data for per patient CT diagnostic accuracy were sensitivity 83 % (95 % CI 79–86 %), specificity 86 % (95 % CI 82–89 %), pooled positive LR 4.37 (2.58–7.41), and pooled negative LR 0.20 (0.11–0.35). On a per region basis CT performed best in epigastrium and pelvis. Correlation analysis showed a high correlation between CT-PCI and surgical-PCI scores, ranging from 0.49 to 0.96. MRI and PET/CT achieved similar per patient diagnostic accuracy.

Conclusions

CT should be the preferred diagnostic imaging modality for detecting peritoneal metastases because of the robustness of the data. MRI and PET/CT should be considered second choices, until more consistent information on their diagnostic yield in detecting PM are obtained.

Keywords

Peritoneal carcinomatosis Computed tomography Magnetic resonance imaging Accuracy Peritoneal Cancer Index 

Abbreviations

CT

Computed tomography

PET/CT

Positron emission tomography/computed tomography

MRI

Magnetic resonance imaging

PM

Peritoneal metastases

PCI

Peritoneal Cancer Index

HIPEC

Hyperthermic intraperitoneal chemotherapy

Notes

Acknowledgments

We have nothing to disclose.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

11547_2016_682_MOESM1_ESM.docx (84 kb)
Supplementary material 1 (DOCX 83 kb)

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Copyright information

© Italian Society of Medical Radiology 2016

Authors and Affiliations

  • Andrea Laghi
    • 1
    Email author
  • Davide Bellini
    • 1
  • Marco Rengo
    • 1
  • Fabio Accarpio
    • 2
  • Damiano Caruso
    • 1
  • Daniele Biacchi
    • 2
  • Angelo Di Giorgio
    • 2
  • Paolo Sammartino
    • 2
  1. 1.Department of Radiological Sciences, Oncology and Pathology“SAPIENZA” University of Rome, I.C.O.T. HospitalLatinaItaly
  2. 2.Department of Surgery “P. Valdoni”“SAPIENZA” University of RomeRomeItaly

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