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La radiologia medica

, Volume 120, Issue 12, pp 1083–1093 | Cite as

Hepatic fat quantification using the proton density fat fraction (PDFF): utility of free-drawn-PDFF with a large coverage area

  • Kun Young Kim
  • Ji Soo SongEmail author
  • Stephan Kannengiesser
  • Young Min Han
ABDOMINAL RADIOLOGY

Abstract

Purpose

To evaluate the diagnostic performance of magnetic resonance imaging-estimated proton density fat fraction (MRI-PDFF) using a free-drawn region-of-interest (ROI) measurement of hepatic fat deposition compared to MR spectroscopy (MRS) as the reference standard.

Materials and methods

A total of 156 patients underwent 3T MR imaging with a multi-step adaptive fitting approach, multi-echo volume interpolated breath-hold examination (VIBE) acquisition and single-voxel high-speed T2-corrected multiple-echo 1H-MR spectroscopy (SVS). Seven ROI measurements were performed in each segment of the fat percentage maps (“segmental-PDFF”). Three ROIs were placed at the same level as the SVS (“VOI-PDFF”). Free-hand-drawn ROIs were placed at three different levels along the entire liver (“free-drawn-PDFF”) and separately along the right and left lobes (“free-drawn-PDFF-2”).

Results

A strong correlation was found between VOI-PDFF and SVS (r = 0.977). The right lobe had greater fat content than the left lobe (p < 0.001). After image analysis, 54 and 46 patients were classified as having steatosis using SVS and free-drawn-PDFF as a reference standard, respectively. The diagnostic performance of free-drawn-PDFF was significantly different from SVS (p < 0.05).

Conclusion

Free-drawn-PDFF provides accurate and generalized information regarding hepatic fat deposition. It is a useful method, particularly if fat deposition is heterogeneous, and should be considered as a new reference standard.

Keywords

Fat quantification Proton density fat fraction Hepatic steatosis MR spectroscopy 

Notes

Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of human rights

For this type of study formal consent is not required.

Ethical standard

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Italian Society of Medical Radiology 2015

Authors and Affiliations

  • Kun Young Kim
    • 1
  • Ji Soo Song
    • 1
    Email author
  • Stephan Kannengiesser
    • 2
  • Young Min Han
    • 1
  1. 1.Department of Radiology, Chonbuk National University Medical School and HospitalResearch Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University HospitalJeonju-SiKorea
  2. 2.MR Applications DevelopmentSiemens HealthcareErlangenGermany

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