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La radiologia medica

, Volume 118, Issue 7, pp 1199–1211 | Cite as

Evolution of ventriculomegaly: comparison between foetal MR imaging and postnatal diagnostic imaging

  • Sara Mehrabi
  • Alessia Adami
  • Anna Ventriglia
  • Lisa Zantedeschi
  • Massimo Franchi
  • Riccardo Manfredi
Paediatric Radiology / Radiologia Pediatrica
  • 112 Downloads

Abstract

Purpose

We evaluated the evolution of ventriculomegaly (VM) by comparing foetal magnetic resonance imaging (MRI) with postnatal transcranial ultrasonography (US) and/or encephalic MRI.

Materials and methods

Between January 2006 and April 2011, 70 foetuses with a mean gestational age of 28 weeks and 4 days (range, 18–36) weeks with VM on foetal MRI were assessed in this prospective study. Half-Fourier rapid acquisition with relaxation enhancement (RARE) T2-weighted, T1-weighted and diffusion-weighted (DWI) images along the three orthogonal planes according to the longitudinal axis of the mother, and subsequently of the foetal brain, were acquired. Quantitative image analysis included the transverse diameter of lateral ventricles in axial and coronal planes. Qualitative image analysis included searching for associated structural anomalies.

Results

Thirty-four of 70 patients with a diagnosis of VM on foetal MRI underwent postnatal imaging. Twenty-five of those 34 (73%) had mild, four (12%) had moderate and five (15%) had severe VM on MRI. Normalisation of the diameter of lateral ventricles was observed in 16 of the 34 (47%) newborns. Among these 16, 13 (81%) had mild and three (19%) had moderate VM (two isolated and one associated VM). VM stabilisation was observed in 16 of the 34 (47%) babies. Among them, 11 (69%) had mild (eight isolated and three associated), one (6%) had moderate associated and four (25%) had severe associated VM. Progression from mild to severe (associated) VM was observed in two of the 34 (6%) babies.

Conclusions

The absence of associated anomalies and a mild VM are favourable prognostic factors in the evolution of VM.

Keywords

Foetal imaging MRI Intrauterine diagnosis Congenital Foetus 

Evoluzione della ventricolomegalia: confronto tra RM fetale e indagini diagnostiche post-natali

Riassunto

Obiettivo

Scopo del presente lavoro è stato valutare l’evoluzione della ventricolomegalia (VM), confrontando la risonanza magnetica (RM) fetale con le indagini diagnostiche post-natali ottenute mediante ecografia transfontanellare e/o RM encefalo.

Materiali e metodi

Tra gennaio 2006 e aprile 2011, 70 feti di età gestazionale media di 28 settimane e 4 giorni (range 18-36 settimane) con VM alla RM fetale sono stati inclusi in questo studio prospettico. Sono state eseguite immagini T2-dipendenti Half Fourier RARE lungo i tre piani ortogonali all’asse longitudinale materno e all’encefalo fetale, immagini T1-dipendenti e sequenze in diffusione. L’analisi quantitativa ha compreso la misura del diametro trasversale dei ventricoli laterali sui piani assiale e coronale. L’analisi qualitativa ha compreso la ricerca di eventuali anomalie strutturali associate.

Risultati

Trentaquattro pazienti su settanta presentavano diagnosi di VM alla RM fetale e avevano effettuato un controllo post-natale. Alla RM fetale 25/34 (73%) neonati presentavano VM lieve, 4/34 (12%) VM moderata, 5/34 (15%) VM severa. In 16/34 (47%) neonati c’è stata una normalizzazione dei ventricoli laterali. In 13/16 (81%) neonati la RM fetale aveva mostrato la presenza di VM lieve. Tre su sedici (19%) neonati presentavano VM moderata alla RM fetale (2/3 isolata, 1/3 associata). In 16/34 (47%) neonati è stata riscontrata una stabilità della VM. In 11/16 (69%) neonati la RM fetale aveva mostrato VM lieve (8/11 isolata, 3/11 associata), 1/16 (6%) neonato VM moderata associata, 4/16 (25%) neonati VM severa associata. In 2/34 (6%) neonati c’è stata una progressione della dilatazione dei ventricoli laterali da lieve a severa (associata).

Conclusioni

L’assenza di anomalie associate alla VM e la presenza di una VM di basso grado sono fattori prognostici favorevoli per l’evoluzione della VM.

Parole chiave

Imaging fetale RM Diagnosi intrauterina Congenito Feto 

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Copyright information

© Springer-Verlag 2013

Authors and Affiliations

  • Sara Mehrabi
    • 1
  • Alessia Adami
    • 1
  • Anna Ventriglia
    • 1
  • Lisa Zantedeschi
    • 1
  • Massimo Franchi
    • 2
  • Riccardo Manfredi
    • 1
  1. 1.Istituto di RadiologiaUniversità di Verona, Policlinico G.B. RossiVeronaItaly
  2. 2.Dipartimento di Ginecologia ed OstetriciaUniversità di Verona, Policlinico G.B. RossiVeronaItaly

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