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La radiologia medica

, Volume 117, Issue 2, pp 282–292 | Cite as

Quantitative MRCP assessment of pancreatic exocrine reserve and its correlation with faecal elastase-1 in patients with chronic pancreatitis

  • R. ManfrediEmail author
  • S. Perandini
  • W. Mantovani
  • L. Frulloni
  • N. Faccioli
  • R. Pozzi Mucelli
Abdominal Radiology / Radiologia Addominale

Abstract

Purpose

This retrospective study was done to correlate a quantitative assessment of the pancreatic exocrine reserve by dynamic secretin magnetic resonance cholangiopancreatography (MRCPQ) with the faecal elastase-1 (FE-1) test in patients with chronic pancreatitis.

Materials and methods

Thirty-five patients with a clinical diagnosis of chronic (CP) or acute recurrent (ARP) pancreatitis were enrolled. FE-1 was indicative of the pancreatic exocrine reserve. Subsequently, the patient population was subdivided into two groups according to a clinical threshold value of 200 μg/g. All patients underwent MRCP examination during secretin administration. Duodenal filling volume was calculated on T2-weigthed rapid acquisition with relaxation enhancement (RARE) MRCP images obtained 10 min after secretin injection. Duodenal filling volumes were compared with FE-1 values. Scatter plots, Pearson correlation coefficient and the Mann-Whitney U test were performed.

Results

Thirty-five paired MRCPQ-FE1 data sets were analysed. MRCPQ was significantly different (p=0.007) between patients with impaired and preserved pancreatic function; median and interquartile range (IQR) were 150.7 ml (137.3–205.5 ml; n=9) and 332.4 ml (190.6–506.9 ml; n=26). Both Pearson correlation coefficient (p<0.001) and the Mann-Whitney U test (p=0.007) were significant.

Conclusions

MRCPQ significantly correlates with FE-1 values. It is possible to discriminate impaired and preserved pancreatic exocrine function using MRCPQ.

Keywords

MRCPQ Chronic pancreatitis Pancreatic exocrine reserve Quantitative MR Secretin 

Valutazione quantitativa della riserva pancreatica esocrina per mezzo della colangiopancreatografia con risonanza magnetica e sua correlazione con l’elastasi fecale-1 nei pazienti con pancreatite cronica

Riassunto

Obiettivo

Scopo del presente studio è stato identificare una correlazione tra la valutazione quantitativa della riserva pancreatica esocrina tramite l’utilizzo della colangiopancreatografia con risonanza magnetica durante lo stimolo secretinico (CPRMQ) ed il test della elastasi fecale-1 (FE-1) nei pazienti con pancreatite cronica.

Materiali e metodi

Trentacinque pazienti con una diagnosi clinica di pancreatite cronica o di pancreatiti acute ricorrenti sono stati reclutati in questo studio retrospettico. I valori di FE-1 sono stati utilizzati per quantificare la riserva pancreatica esocrina; successivamente i pazienti sono stati suddivisi in due gruppi a seconda di un valore soglia clinico di FE-1 di 200 μg/g. Tutti i pazienti sono stati sottoposti a CPRM con stimolo secretinico. Il volume di riempimento duodenale è stato calcolato su immagini CPRM rapid acquisition with relaxation enhancement (RARE) T2-dipendenti, ottenute 10 min dopo l’iniezione di secretina. I volumi di riempimento duodenale sono stati comparati con il valore di FE-1. Sono stati valutati grafici di dispersione, il coefficiente di correlazione di Pearson ed il test U di Mann-Whitney.

Risultati

Trentacinque coppie di dati CPRMQ-FE-1 sono state analizzate. La CPRMQ è risultata significativamente differente (p=0,007) tra il gruppo con funzione pancreatica ridotta e quello con funzione normale; mediana e range interquartilico (IQR) sono stati di 150,7 ml (137,3-205,5 ml; n=9) e 332,4 ml (190,6-506,9 ml; n=26). Sia il coefficiente di correlazione di Pearson (p<0,001) che il test U di Mann-Whitney (p=0,007) si sono dimostrati significativi.

Conclusioni

La CPRM quantitativa correla positivamente con i valori FE-1. è possibile discriminare una funzione pancreatica esocrina conservata da una ridotta per mezzo della CPRMQ.

Parole chiave

CPRMQ Pancreatite cronica Riserva esocrina pancreatica Risonanza magnetica quantitativa Secretina 

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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • R. Manfredi
    • 1
    Email author
  • S. Perandini
    • 1
  • W. Mantovani
    • 3
  • L. Frulloni
    • 2
  • N. Faccioli
    • 1
  • R. Pozzi Mucelli
    • 1
  1. 1.Istituto di RadiologiaUniversità di VeronaVeronaItaly
  2. 2.Istituto di Scienze Chirurgiche e BiomedicheUniversità di VeronaVeronaItaly
  3. 3.Istituto di Medicina e Salute PubblicaUniversità di VeronaVeronaItaly

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