La radiologia medica

, Volume 117, Issue 5, pp 885–891 | Cite as

Does weight loss predict accuracy of setup in head and neck cancer patients treated with Intensity-Modulated Radiation Therapy?

  • B. De Bari
  • M. Ait Erraisse
  • T. Chekrine
  • M. Rabilloud
  • I. Shakir Shakir
  • L. Lebras
  • V. Favrel
Radiotherapy / Radioterapia



This prospective study reports the impact of weight loss on setup of head and neck (H&N) cancer patients treated by Intensity-Modulated Radiation Therapy (IMRT).

Materials and methods

Setup errors of H&N cancer patients treated by IMRT from January to June 2010 were prospectively analysed and statistically related to weight loss. A mixed linear model was used for statistical evaluations. Setup margins of our institute were also calculated.


Twenty-two patients and 128 pairs of Electronic Portal Images (EPI) were analysed. Setup errors varied between −0.6 and +0.6, −0.7 and +0.8 and −0.2 and +0.8 in the anterior-posterior, superior-inferior and right-left direction, respectively. Median and mean weight loss were 2.1 and 3.1 kg (range 0–12 kg), respectively; median and mean percent of weight loss were 2.95% and 4.64% (range 0.3–19.7%), respectively. No statistical relation was seen between weight loss and the setup errors.


Weight loss is not a good clinical parameters for predicting an increase of setup errors. Other clinical and/or anthropometrical features should be prospectively evaluated in order to assess the need for re-planning.


Adaptive radiotherapy Head and neck cancers IMRT Setup margins Weight loss 

Può la perdita di peso predire l’accuratezza del setup nei pazienti trattati con Radioterapia ad Intensità Modulata per un tumore della testa e del collo ?



Questo studio prospettico valuta l’impatto della perdita di peso sul setup dei pazienti H&N trattati tramite Radioterapia ad Intensità Modulata (IMRT).

Materiali e Metodi

Gli errori di setup dei pazienti H&N trattati con IMRT dal 01/2010 al 06/2010 sono stati analizzati in maniera prospettica e correlati statisticamente alla perdita di peso. Un modello lineare misto è stato usato per l’analisi statistica. I margini di setup della nostra istituzione son stati calcolati e riportati.


22 pazienti e 128 coppie di Immagini Portali (PI) sono stati analizzati. Gli errori di setup variavano tra −0,6 e +0,6, −0,7 e +0,8 e −0,2 e +0,8 cm, rispettivamente in direzione antero-posteriore, supero-inferiore and latero-laterale. La perdita mediana e media di peso sono state rispettivamente di 2,1 e 3,1 kg (range 0–12 kg), mentre la riduzione mediana e media di peso in % é stata rispettivamente di di 2,95% e 4,64% (range: 0,3%–19,7%). Nessuna relazione statistica tra la perdita di peso e gli errori di setup è stata messa in evidenza.


La perdita di peso non è un buon parametro clinico per predire l’aumento degli errori di setup. Altri criteri clinici e/o antropomorfici devono essere valutati in maniera prospettica per stabilire la necessità di un replanning.

Parole chiave

Radioterapia adattativa Tumori della testa e del collo IMRT Margini di setup Perdita di peso 


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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • B. De Bari
    • 1
    • 2
  • M. Ait Erraisse
    • 1
    • 2
  • T. Chekrine
    • 1
    • 2
  • M. Rabilloud
    • 3
  • I. Shakir Shakir
    • 1
    • 2
  • L. Lebras
    • 1
    • 2
  • V. Favrel
    • 1
    • 2
  1. 1.Département de Radiothérapie OncologieCentre Hospitalier Lyon SudPierre-BéniteFrance
  2. 2.EA3738Université Claude-BernardLyonFrance
  3. 3.Service de BiostatistiqueUniversité Lyon-SudPierre Bénite CedexFrance

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