La radiologia medica

, Volume 114, Issue 2, pp 173–189 | Cite as

Radiological-pathological correlation in intratumoural tissue components of solid lung tumours

  • E. Quaia
  • E. Baratella
  • R. Pizzolato
  • R. Bussani
  • M. A. Cova
Chest Radiology Radiologia Toracica

Abstract

The aim of this paper is to describe the intratumoural tissue components of solid lung tumours evidenced by macroscopic and/or microscopic examination of the autopsic or surgical specimen and visible on computed tomography (CT) without and with contrast material administration. Seven intratumoural tissue components can be identified both at CT and at pathology: (1) solid component, (2) haemorrhagic component, (3) coagulation necrosis, (4) liquefactive necrosis, (5) parenchymal consolidation, (6) diffuse peripheral component and (7) fibrotic component. Necrotic and haemorrhagic components are typically observed in malignant lesions, whereas solid and fibrotic components may be seen both in solid lung malignancies and in benign lesions.

Keywords

Lung tumours CT Radiological-pathological correlation 

Correlazione tra immagini radiologiche ed anatomia patologica nelle componenti tissutali intratumorali dei tumori polmonari solidi

Riassunto

Lo scopo di questa presentazione è descrivere le componenti tissutali intratumorali presenti nei tumori polmonari solidi che risultino evidenti all’analisi macroscopica e/o microscopica del campione patologico, autoptico oppure chirurgico, e che siano identificabili anche all’indagine tomografia computerizzata (TC) eseguita mediante metodica diretta e dopo la somministrazione di mezzo di contrasto. Sette distinte componenti tissutali intratumorali sono identificabili sulle immagini TC e sul reperto patologico: 1) componente solida; 2) componente emorragica; 3) necrosi coagulativa; 4) necrosi colliquativa; 5) addensamento parenchimale; 6) componente periferica diffusa; 7) componente fibrotica. Le componenti a carattere necrotico ed emorragico vengono osservate tipicamente nelle neoplasie maligne, mentre le componenti solide ed a carattere fibrotico possono essere osservate sia nei processi polmonari solidi a carattere maligno sia nelle lesioni benigne.

Parole chiave

Tumori polmonari TC Correlazioni radiologia ed anatomia patologica 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References/Bibliografia

  1. 1.
    Ambrosone CB, Rao U, Michalek AM et al (1993) Lung cancer histologic types and family history of cancer: analysis of histologic subtypes of 872 patients with primary lung cancer. Cancer 72:1192–1198PubMedCrossRefGoogle Scholar
  2. 2.
    Spiro SG, Porter JC (2002) Lung cancer — Where are we today? Current advances in staging and nonsurgical treatment. Am J Respir Crit Care Med 166:1166–1196PubMedCrossRefGoogle Scholar
  3. 3.
    Greene FL, Page DL, Fleming ID et al (2002) In: AJCC Cancer Staging Manual. Springer, Berlin Heidelberg New York, 165–177CrossRefGoogle Scholar
  4. 4.
    Zwirewich CV, Vedal S, Miller RR, Muller NL (1991) Solitary pulmonary nodule: high resolution CT and radiologic-pathologic correlation. Radiology 179:469–476PubMedGoogle Scholar
  5. 5.
    Rosado-de-Christenson ML, Templeton PA, Moran CA (1994) From the Archives of the AFIP. Bronchogenic carcinoma: radiologic-pathologic correlation. Radiographics 14:429–446PubMedGoogle Scholar
  6. 6.
    Lindell RM, Hartman TE, Swensen SJ et al (2007) Five-year lung cancer screening experience: CT appearance, growth rate, location, and histologic features of 61 lung cancers. Radiology 242:555–562PubMedCrossRefGoogle Scholar
  7. 7.
    Sone S, Sakai F, Takashima S et al (1997) Factors affecting the radiologic appearance of peripheral bronchogenic carcinomas. J Thorac Imaging 12:159–172PubMedCrossRefGoogle Scholar
  8. 8.
    Jeong YJ, Lee KS, Jeong SY et al (2005) Solitary pulmonary nodule: characterization with combined wash-in and washout features at dynamic multidetector row CT. Radiology 237:675–683PubMedCrossRefGoogle Scholar
  9. 9.
    Yi CA, Lee KS, Kim BT et al (2006) Tissue characterization of solitary pulmonary nodule: comparative study between helical dynamic CT and integrated PET/CT. J Nucl Med 47:443–450PubMedGoogle Scholar
  10. 10.
    Lee KS, Yi CA, Jeong SY et al (2007) Solid or partly solid solitary pulmonary nodules: their characterization using contrast wash-in and morphologic features at helical CT. Chest 131:1516–1525PubMedCrossRefGoogle Scholar
  11. 11.
    Kondo T, Yamada K, Noda K et al (2002) Radiologic — pathologic correlation in patients with small pulmonary acenocarcinomas. Lung Cancer 36:49–57PubMedCrossRefGoogle Scholar
  12. 12.
    Suzuki K, Kusumoto M, Watanabe S et al (2006) Radiologic classification of small adenocarcinoma of the lung: radiologic — pathologic correlation and its prognostic impact. Ann Thorac Surg 81:413–419PubMedCrossRefGoogle Scholar
  13. 13.
    Lee KS, Kim Y, Han J et al (1997) Bronchioloalveolar carcinoma: clinical, histopathologic, and radiologic findings. Radiographics 17:1345–1357PubMedGoogle Scholar
  14. 14.
    Gaeta M, Caruso R, Blandino A et al (1999) Radiolucencies and cavitation in bronchioloalveolar carcinoma: CT — pathologic correlation. Eur Radiol 9:55–59PubMedCrossRefGoogle Scholar
  15. 15.
    Kobashi Y, Fukuda M, Nakata M et al (2006) Inflammatory pseudotumor of the lung: clinicopathological analysis in seven adult patients. Int J Clin Oncol 11:461–466PubMedCrossRefGoogle Scholar
  16. 16.
    Lee JY, Lee KS, Jung KJ et al (2000) Pulmonary tuberculosis: CT and pathologic correlation. J Comput Assist Tomogr 24:691–698PubMedCrossRefGoogle Scholar
  17. 17.
    Yang X, Yan H, Xie Y et al (1996) Vascular manifestations of small solitary pulmonary masses. Angiographic-pathologic correlations and clinical significance. Invest Radiol 31:275–279PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • E. Quaia
    • 1
  • E. Baratella
    • 1
  • R. Pizzolato
    • 1
  • R. Bussani
    • 2
  • M. A. Cova
    • 1
  1. 1.Unità Clinica Operativa di RadiologiaUniversità di TriesteTriesteItaly
  2. 2.Unità Clinica Operativa di Anatomia ed Istologia Patologica, Ospedale di CattinaraUniversità di TriesteTriesteItaly

Personalised recommendations