Ordinary Differential Equation Models for Adoptive Immunotherapy
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Modified T cells that have been engineered to recognize the CD19 surface marker have recently been shown to be very successful at treating acute lymphocytic leukemias. Here, we explore four previous approaches that have used ordinary differential equations to model this type of therapy, compare their properties, and modify the models to address their deficiencies. Although the four models treat the workings of the immune system in slightly different ways, they all predict that adoptive immunotherapy can be successful to move a patient from the large tumor fixed point to an equilibrium with little or no tumor.
KeywordsChimeric antigen receptor T cells ODE models Stability analysis Saturating response Acute lymphoblastic leukemia
Funding was provided by National Science Foundation (Grant No. DMS 1505215).
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