Autocatalytic Sets and Biological Specificity
A universal feature of the biochemistry of any living system is that all the molecules and catalysts that are required for reactions of the system can be built up from an available food source by repeated application of reactions from within that system. RAF (reflexively autocatalytic and food-generated) theory provides a formal way to study such processes. Beginning with Kauffman’s notion of “collectively autocatalytic sets,” this theory has been further developed over the last decade with the discovery of efficient algorithms and new mathematical analysis. In this paper, we study how the behaviour of a simple binary polymer model can be extended to models where the pattern of catalysis more precisely reflects the ligation and cleavage reactions involved. We find that certain properties of these models are similar to, and can be accurately predicted from, the simple binary polymer model; however, other properties lead to slightly different estimates. We also establish a number of new results concerning the structure of RAFs in these systems.
KeywordsOrigin of life Autocatalytic sets Template-based catalysis Wills–Henderson model
- Crick, F. H. C. (1958). On protein synthesis. Symp. Soc. Exp. Biol., 12, 138–163. Google Scholar
- Kauffman, S. A. (1993). The origins of order. Oxford: Oxford University Press. Google Scholar
- Schrödinger, E. (1944). What is life? Cambridge: Cambridge University Press. Google Scholar
- Wills, P., & Henderson, L. (2000). Self-organisation and information-carrying capacity of collectively autocatalytic sets of polymers: ligation systems. In Y. Bar-Yam (Ed.), Unifying themes in complex systems: proceedings of the first international conference on complex systems (pp. 613–623). Jackson: Perseus. Google Scholar