Bulletin of Mathematical Biology

, Volume 75, Issue 1, pp 82–93 | Cite as

The Impact of Hepatitis A Virus Infection on Hepatitis C Virus Infection: A Competitive Exclusion Hypothesis

  • Marcos Amaku
  • Francisco Antonio Bezerra Coutinho
  • Eleazar Chaib
  • Eduardo Massad
Original Article


We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings.


Hepatitis A Hepatitis C Competitive exclusion principle Mathematical models 


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Copyright information

© Society for Mathematical Biology 2012

Authors and Affiliations

  • Marcos Amaku
    • 1
  • Francisco Antonio Bezerra Coutinho
    • 2
    • 3
  • Eleazar Chaib
    • 2
    • 3
  • Eduardo Massad
    • 2
    • 3
    • 4
  1. 1.School of Veterinary MedicineUniversity of São PauloSão PauloBrazil
  2. 2.School of MedicineUniversity of São PauloSão PauloBrazil
  3. 3.LIM 01-HCFMUSPSão PauloBrazil
  4. 4.London School of Hygiene and Tropical MedicineLondonUK

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