Chemical Reaction Systems with Toric Steady States
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Mass-action chemical reaction systems are frequently used in computational biology. The corresponding polynomial dynamical systems are often large (consisting of tens or even hundreds of ordinary differential equations) and poorly parameterized (due to noisy measurement data and a small number of data points and repetitions). Therefore, it is often difficult to establish the existence of (positive) steady states or to determine whether more complicated phenomena such as multistationarity exist. If, however, the steady state ideal of the system is a binomial ideal, then we show that these questions can be answered easily. The focus of this work is on systems with this property, and we say that such systems have toric steady states. Our main result gives sufficient conditions for a chemical reaction system to have toric steady states. Furthermore, we analyze the capacity of such a system to exhibit positive steady states and multistationarity. Examples of systems with toric steady states include weakly-reversible zero-deficiency chemical reaction systems. An important application of our work concerns the networks that describe the multisite phosphorylation of a protein by a kinase/phosphatase pair in a sequential and distributive mechanism.
KeywordsChemical reaction networks Mass-action kinetics Multistationarity Multisite phosphorylation Binomial ideal
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- Angeli, D., De Leenheer, P., & Sontag, E. (2007). A Petri net approach to persistence analysis in chemical reaction networks. In I. Queinnec, S. Tarbouriech, G. Garcia, & S.-I. Niculescu (Eds.), Lecture notes in control and information sciences: Vol. 357. Biology and Control Theory: Current Challenges (pp. 181–216). Berlin: Springer. CrossRefGoogle Scholar
- Conradi, C., Dickenstein, A., Pérez Millán, M., & Shiu, A. (2010). Counting positive roots of polynomials with applications for biochemical systems. In preparation. Google Scholar
- Conradi, C., Saez-Rodriguez, J., Gilles, E.-D., & Raisch, J. (2005). Using Chemical Reaction Network Theory to discard a kinetic mechanism hypothesis. IEE Proc. Syst. Biol. (now IET Systems Biology), 152(4), 243–248. Google Scholar
- Holstein, K. (2008). Mathematische analyse der n-fachen Phosphorylierung eines Proteins: Existenz mehrfach stationärer Zustände. Master’s thesis, Diplomarbeit, Universität Magdeburg. Google Scholar