Bulletin of Mathematical Biology

, Volume 69, Issue 6, pp 1791–1813 | Cite as

Propagation of Fluctuations in Biochemical Systems, I: Linear SSC Networks

  • David F. Anderson
  • Jonathan C. Mattingly
  • H. Frederik Nijhout
  • Michael C. ReedEmail author
Original Article


We investigate the propagation of random fluctuations through biochemical networks in which the number of molecules of each species is large enough so that the concentrations are well modeled by differential equations. We study the effect of network topology on the emergent properties of the reaction system by characterizing the behavior of variance as fluctuations propagate down chains and studying the effect of side chains and feedback loops. We also investigate the asymptotic behavior of the system as one reaction becomes fast relative to the others.


Biochemical systems Fluctuations Stochastic differential equations 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • David F. Anderson
    • 1
  • Jonathan C. Mattingly
    • 1
  • H. Frederik Nijhout
    • 2
  • Michael C. Reed
    • 1
    Email author
  1. 1.Department of MathematicsDuke UniversityDurhamUSA
  2. 2.Department of BiologyDuke UniversityDurhamUSA

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