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Targeted Oncology

, Volume 12, Issue 1, pp 11–18 | Cite as

The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences

  • Estelle Willems
  • Arnaud Lombard
  • Matthias Dedobbeleer
  • Nicolas Goffart
  • Bernard Rogister
Review Article

Abstract

The main obstacle for the cure of glioblastoma (GBM) is systematic tumor recurrence after treatment. More than 90 % of GBM tumors are indeed recurrent within 5 years after diagnosis and treatment. We urgently need new therapies to specifically address these deadly relapses. A major advance in the understanding of GBM recurrence is the identification of GBM-Initiating Cells (GIC), characterized by their abilities for self-renewal, multilineage differentiation, and proliferation. It appears that these features of GIC could be modulated by the mitotic kinase Aurora A (AurA). Indeed, besides its role in mitosis, AurA has recently been identified to regulate alternative functions like cell polarity, asymmetric cell division, and epithelial to mesenchymal transition. All these properties may help explain GBM therapeutic resistance and recurrence. In this review, we make the hypothesis that AurA could significantly contribute to GBM recurrences and we focus on the possible roles of AurA in GIC.

Keywords

Cancer Stem Cell Normal Stem Cell Asymmetrical Cell Division Spindle Orientation Centrosome Position 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors are grateful to David Halzen for the help in English usage and style.

Compliance with Ethical Standards

Funding

This work was supported by grants from the National Fund for Scientific Research (F.N.R.S/Télévie); the Special Funds of the University of Liège; an Anti-Cancer Center near the University of Liège and a Léon Frédéricq Grant.

Conflict of Interest

Estelle Willems, Arnaud Lombard, Matthias Dedobbeleer, Nicolas Goffart and Bernard Rogister declare no conflicts of interest.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Estelle Willems
    • 1
  • Arnaud Lombard
    • 1
    • 2
  • Matthias Dedobbeleer
    • 1
  • Nicolas Goffart
    • 3
    • 4
  • Bernard Rogister
    • 1
    • 5
  1. 1.Laboratory of Nervous System Diseases and Therapy, GIGA-NeurosciencesUniversity of LiègeLiègeBelgium
  2. 2.Department of NeurosurgeryCHU and University of LiègeLiègeBelgium
  3. 3.Department of Human Genetics, GIGA-CancerUniversity of LiègeLiègeBelgium
  4. 4.The T&P Bohnenn Laboratory for Neuro-Oncology, Department of NeurosurgeryUMC UtrechtUtrechtThe Netherlands
  5. 5.Department of NeurologyCHU and University of LiègeLiègeBelgium

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