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Targeted Oncology

, Volume 10, Issue 4, pp 549–555 | Cite as

The Association of Serum Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Thymidine Kinase, and Tissue Polypeptide Specific Antigen with Outcomes of Patients with Metastatic Colorectal Cancer Treated with Bevacizumab: a Retrospective Study

  • Ondrej Fiala
  • Jindrich Finek
  • Tomas Buchler
  • Vit Martin Matejka
  • Lubos Holubec
  • Jana Kulhankova
  • Zbynek Bortlicek
  • Vaclav Liska
  • Ondrej Topolcan
Original Research

Abstract

The aim of our retrospective study was to analyze the association of selected tumor markers (TMs) including serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), thymidine kinase, and tissue polypeptide specific antigen with outcomes in patients with metastatic colorectal cancer (mCRC) treated with bevacizumab. There is an increasing body of evidence from retrospective/observational studies that some serum TMs may be predictive of effect of targeted therapies in mCRC. In our study, the cohort included 152 patients treated with bevacizumab-based therapy between years 2005 and 2014 at Department of Oncology and Radiotherapy, Medical School and Teaching Hospital Pilsen. Serum samples for measurement of TMs were collected within 1 month before the initiation of bevacizumab-based treatment. In multivariate Cox analysis that included serum tumor markers and clinical baseline parameters, the number of metastatic sites (hazard ratio [HR] = 2.00, p = 0.001) and CEA levels (HR = 2.80, p < 0.001) were significantly associated with progression-free survival, whereas CA 19-9 levels (HR = 2.25, p = 0.008) were the only studied parameter associated with overall survival. Quantification of serum CEA and CA 19-9 is simple and readily available, and their candidate prognostic importance in the setting of antiangiogenesis therapy deserves to be studied in prospective trials.

Keywords

Vascular Endothelial Growth Factor Bevacizumab Thymidine Kinase Serum Tumor Marker Tissue Polypeptide Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to thank all patients voluntarily taking part in the observational, population-based registry CORECT. This study is supported by the Ministry of Health, Czech Republic—conceptual development of research organization Faculty Hospital in Pilsen—FNPl, 00669806 and by the project CZ.1.05/2.1.00/03.0076 from the European Regional Development Fund.

Conflict of Interest

JF has received honoraria from Astra Zeneca, Roche, and Novartis for consultations and lectures unrelated to this project. TB has received honoraria from Roche for consultations and lectures unrelated to this project. OF, VMM, LH, JK, ZB, VL, and OT declare that they have no actual or potential conflict of interest including any financial, personal, or other relationships with other people or organizations that could inappropriately influence this work.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Ondrej Fiala
    • 1
    • 2
  • Jindrich Finek
    • 1
  • Tomas Buchler
    • 3
  • Vit Martin Matejka
    • 1
  • Lubos Holubec
    • 1
    • 2
  • Jana Kulhankova
    • 1
  • Zbynek Bortlicek
    • 4
  • Vaclav Liska
    • 2
    • 5
  • Ondrej Topolcan
    • 6
  1. 1.Department of Oncology and Radiotherapy, Medical School and Teaching Hospital in PilsenCharles University in PraguePilsenCzech Republic
  2. 2.Biomedical Center, Faculty of Medicine in PilsenCharles University in PraguePilsenCzech Republic
  3. 3.Department of Oncology and First Faculty of MedicineCharles University and Thomayer HospitalPragueCzech Republic
  4. 4.Institute of Biostatistics and Analyses, Faculty of MedicineMasaryk UniversityBrnoCzech Republic
  5. 5.Department of Surgery, Medical School and Teaching Hospital in PilsenCharles University in PraguePilsenCzech Republic
  6. 6.Department of Nuclear Medicine, Medical School and Teaching Hospital in PilsenCharles University in PraguePilsenCzech Republic

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