Targeted Oncology

, Volume 10, Issue 3, pp 311–324 | Cite as

Treatment of advanced thyroid cancer: role of molecularly targeted therapies

  • Lorinda L. Covell
  • Apar Kishor GantiEmail author


Advanced thyroid cancer is not amenable to therapy with conventional cytotoxic chemotherapy. However, newer advances in the understanding of the molecular pathogenesis of different subtypes of thyroid cancer have provided new opportunities for the evaluation of molecularly targeted therapies. This has led to multiple clinical trials using various multi-kinase inhibitors and the subsequent US FDA approval of sorafenib for differentiated thyroid cancer and vandetanib and cabozantinib for medullary thyroid carcinoma. This review provides a summary of the current literature for the treatment of advanced thyroid carcinoma and future directions in this disease.


Molecularly targeted therapies Multi-kinase inhibitors Thyroid cancer 


Conflict of interest

Dr. Covell has nothing to disclose. Dr. Ganti reports personal fees from Boehringer Ingelheim, Otsuka Pharmaceuticals, and Biodesix, Inc, outside the submitted work.


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Copyright information

© Springer International Publishing Switzerland (outside the USA) 2015

Authors and Affiliations

  1. 1.Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Division of Hematology/Oncology, Department of Internal MedicineVA Nebraska-Western Iowa Health Care SystemOmahaUSA
  3. 3.Division of Oncology-Hematology, Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaUSA

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