Targeted Oncology

, Volume 8, Issue 3, pp 211–213 | Cite as

Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series

  • Antoine Italiano
  • Michèle Kind
  • Angela Cioffi
  • Robert G. Maki
  • Binh Bui
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Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients.

Keywords

Desmoplastic round cell tumor Sunitinib Treatment 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag France 2013

Authors and Affiliations

  • Antoine Italiano
    • 1
  • Michèle Kind
    • 2
  • Angela Cioffi
    • 3
  • Robert G. Maki
    • 4
    • 5
  • Binh Bui
    • 1
  1. 1.Department of Medical OncologyInstitut BergonieBordeauxFrance
  2. 2.Department of RadiologyInstitut BergoniéBordeauxFrance
  3. 3.Department of MedicineInstitut Gustave RoussyVillejuifFrance
  4. 4.Sarcoma ServiceMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  5. 5.Mount Sinai School of MedicineNew YorkUSA

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