Targeted Oncology

, Volume 6, Issue 3, pp 163–169

Targets for therapy in ependymoma

Review

DOI: 10.1007/s11523-011-0170-0

Cite this article as:
Shonka, N.A. Targ Oncol (2011) 6: 163. doi:10.1007/s11523-011-0170-0
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Abstract

Ependymomas are among the rarest type of glioma and display significant heterogeneity based on patient age and tumor location. Treatment strategies include surgery and radiation, but the use of chemotherapy remains more controversial. Chemotherapy has been widely utilized in the pediatric population due to more aggressive disease in this cohort, and has become of interest in the adult population as well. Unfortunately, relapses are common, and responses to cytotoxic chemotherapy are often disappointing. As a result, attention has turned to specific targets in the pathogenesis of ependymoma. This paper summarizes the current understanding of promising molecular pathways and targets under study for future application in ependymoma.

Keywords

Ependymoma ErbB2 HER2 neu Lapatanib PDGFR alpha Alpha-v-beta-3 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Division of Oncology & HematologyUniversity of Nebraska Medical CenterOmahaUSA

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