Targeted Oncology

, Volume 5, Issue 1, pp 53–58 | Cite as

Dynamic contrast-enhanced ultrasonography (DCE-US): a new tool for the early evaluation of antiangiogenic treatment

  • Nathalie Lassau
  • Mohamed Chebil
  • Linda Chami
  • Sophie Bidault
  • Elizabeth Girard
  • Alain Roche
Review

Abstract

Dynamic contrast-enhanced ultrasonography (DCE-US) is a new functional technique enabling a quantitative assessment of solid tumor perfusion using raw linear data. DCE-US allows the calculation of parameters as slope of wash-in or area under the curve (AUC) representing, respectively, blood flow or blood volume. Reduction in tumor vascularization can easily be detected in responders after 1 or 2 weeks and is correlated with progression-free survival and overall survival in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). DCE-US is supported by the French National Cancer Institute (INCa), which is currently studying the technique in metastatic breast cancer, melanoma, colon cancer, gastrointestinal stromal tumors and renal cell carcinoma, as well as in primary hepatocellular carcinoma, to establish the optimal perfusion parameters and timing for quantitative anticancer efficacy assessments. Currently 490 patients are included in 20 centers and the preliminary results on 400 patients with 1,096 DCE-US demonstrated that AUC could be a robust parameter to predict response.

Keywords

Doppler-ultrasound Contrast agent Angiogenesis Evaluation of treatment 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Nathalie Lassau
    • 1
    • 2
  • Mohamed Chebil
    • 1
    • 2
  • Linda Chami
    • 1
    • 2
  • Sophie Bidault
    • 1
  • Elizabeth Girard
    • 1
  • Alain Roche
    • 1
    • 2
  1. 1.Imaging DepartmentInstitut Gustave RoussyVillejuifFrance
  2. 2.Imaging Department and IR4M, UMR8081, Ultrasonography UnitInstitut Gustave-RoussyVillejuifFrance

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