Targeted Oncology

, Volume 2, Issue 4, pp 199–210 | Cite as

Molecular targeted therapy for advanced hepatocellular carcinoma

  • Ying Chun Shen
  • Chiun Hsu
  • Ann Lii Cheng


Systemic anticancer therapy for hepatocellular carcinoma (HCC) is limited by intrinsic drug resistance and accompanying liver dysfunction. However, recent advances in molecular targeted therapy (MTT) have shed light on the treatment of advanced HCC. A recent randomized, placebo-controlled trial demonstrated that sorafenib, a multi-target tyrosine kinase inhibitor, prolonged overall survival and time-to-progression in patients with advanced HCC. This breakthrough highlights the potential of MTT targeting hepatocarcinogenic pathways, such as the Raf/MAPK/ERK pathway, angiogenic pathways and the EGFR signaling pathway. This review discusses the current status and the potential of developing novel MTTs for advanced HCC.


Hepatocellular carcinoma Molecular targeted therapy 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ying Chun Shen
    • 1
    • 2
    • 4
  • Chiun Hsu
    • 1
    • 3
    • 4
  • Ann Lii Cheng
    • 1
    • 3
    • 4
  1. 1.Department of OncologyNational Taiwan University HospitalTaipeiTaiwan, R.O.C.
  2. 2.Department of Medical ResearchNational Taiwan University HospitalTaipeiTaiwan, R.O.C.
  3. 3.Internal MedicineNational Taiwan University HospitalTaipeiTaiwan, R.O.C.
  4. 4.National Center of Excellence for Clinical Trial and ResearchNational Taiwan University HospitalTaipeiTaiwan, R.O.C.

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