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Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm

  • Tomohiro Otani
  • Satoshi Ii
  • Tomoyoshi Shigematsu
  • Toshiyuki Fujinaka
  • Masayuki Hirata
  • Tomohiko Ozaki
  • Shigeo WadaEmail author
Original Article

Abstract

Coil embolization of cerebral aneurysms with inhomogeneous coil distribution leads to an incomplete occlusion of the aneurysm. However, the effects of this factor on the blood flow characteristics are still not fully understood. This study investigates the effects of coil configuration on the blood flow characteristics in a coil-embolized aneurysm using computational fluid dynamics (CFD) simulation. The blood flow analysis in the aneurysm with coil embolization was performed using a coil deployment (CD) model, in which the coil configuration was constructed using a physics-based simulation of the CD. In the CFD results, total flow momentum and kinetic energy in the aneurysm gradually decayed with increasing coil packing density (PD), regardless of the coil configuration attributed to deployment conditions. However, the total shear rate in the aneurysm was relatively high and the strength of the local shear flow varied based on the differences in coil configuration, even at adequate PDs used in clinical practice (20–25 %). Because the sufficient shear rate reduction is a well-known factor in the blood clot formation occluding the aneurysm inside, the present study gives useful insight into the effects of coil configuration on the treatment efficiency of coil embolization.

Keywords

Cerebral aneurysm Computational fluid dynamics Coil embolization 

Notes

Acknowledgments

This work was supported in part by the Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research (No. 23650261), JSPS Research Fellowships for Young Scientist (No. 14J01622) and MEXT as a Priority Issue (Integrated computational life science to support personalized and preventive medicine) to be tackled by using post-K computer.

Compliance with ethical standards

Conflict of interest

None.

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Copyright information

© International Federation for Medical and Biological Engineering 2016

Authors and Affiliations

  • Tomohiro Otani
    • 1
  • Satoshi Ii
    • 1
  • Tomoyoshi Shigematsu
    • 2
  • Toshiyuki Fujinaka
    • 2
  • Masayuki Hirata
    • 2
  • Tomohiko Ozaki
    • 2
  • Shigeo Wada
    • 1
    Email author
  1. 1.Department of Mechanical Science and Bioengineering, Graduate School of Engineering ScienceOsaka UniversityToyonakaJapan
  2. 2.Department of Neurosurgery, Graduate School of MedicineOsaka UniversitySuitaJapan

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