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Medical & Biological Engineering & Computing

, Volume 55, Issue 2, pp 327–341 | Cite as

Effects of slow and regular breathing exercise on cardiopulmonary coupling and blood pressure

  • Zhengbo ZhangEmail author
  • Buqing Wang
  • Hao Wu
  • Xiaoke Chai
  • Weidong Wang
  • Chung-Kang Peng
Original Article

Abstract

Investigation of the interaction between cardiovascular variables and respiration provides a quantitative and noninvasive approach to assess the autonomic control of cardiovascular function. The aim of this paper is to investigate the changes of cardiopulmonary coupling (CPC), blood pressure (BP) and pulse transit time (PTT) during a stepwise-paced breathing (SPB) procedure (spontaneous breathing followed by paced breathing at 14, 12.5, 11, 9.5, 8 and 7 breaths per minute, 3 min each) and gain insights into the characteristics of slow breathing exercises. RR interval, respiration, BP and PTT are collected during the SPB procedure (48 healthy subjects, 27 ± 6 years). CPC is assessed through investigating both the phase and amplitude dynamics between the respiration-induced components from RR interval and respiration by the approach of ensemble empirical mode decomposition. It was found that even though the phase synchronization and amplitude oscillation of CPC were both enhanced by the SPB procedure, phase coupling does not increase monotonically along with the amplitude oscillation during the whole procedure. Meanwhile, BP was reduced significantly by the SPB procedure (SBP: from 122.0 ± 13.4 to 114.2 ± 14.9 mmHg, p < 0.001, DBP: from 82.2 ± 8.6 to 77.0 ± 9.8 mmHg, p < 0.001, PTT: from 172.8 ± 20.1 to 176.8 ± 19.2 ms, p < 0.001). Our results demonstrate that the SPB procedure can reduce BP and lengthen PTT significantly. Compared with amplitude dynamics, phase dynamics is a different marker for CPC analysis in reflecting cardiorespiratory coherence during slow breathing exercise. Our study provides a methodology to practice slow breathing exercise, including the setting of target breathing rate, change of CPC and the importance of regular breathing. The applications and usability of the study results have also been discussed.

Keywords

Cardiorespiratory interaction Phase coupling Blood pressure Pulse transit time Stepwise-paced breathing 

Notes

Acknowledgments

This project was supported in part by the Natural Science Foundation of China (Grant Number: 61471398), Beijing Natural Science Foundation (Grant Number: 3122034), General Logistics Science Foundation (Grant Number: CWS11C108) and National Key Technology Research and Development Program (Grant Numbers: 2013BAI03B04, 2013BAI03B05).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© International Federation for Medical and Biological Engineering 2016

Authors and Affiliations

  • Zhengbo Zhang
    • 1
    • 2
    Email author
  • Buqing Wang
    • 1
  • Hao Wu
    • 1
  • Xiaoke Chai
    • 1
  • Weidong Wang
    • 1
  • Chung-Kang Peng
    • 3
    • 4
  1. 1.Department of Biomedical EngineeringChinese PLA (People’s Liberation Army) General HospitalBeijingChina
  2. 2.Harvard-MIT Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.Center for Dynamical Biomarkers and Translational MedicineNational Central UniversityChungliTaiwan
  4. 4.Division of Interdisciplinary Medicine and Biotechnology and Margret and H.A. Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA

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