Medical & Biological Engineering & Computing

, Volume 53, Issue 4, pp 361–370 | Cite as

Improved robust T-wave alternans detectors

  • O. Meste
  • D. Janusek
  • S. Karczmarewicz
  • A. Przybylski
  • M. Kania
  • A. Maciag
  • R. Maniewski
Original Article


New statistical and spectral detectors, the modified matched pairs t test, the extended spectral method and the modified spectral method, were proposed for T-wave alternans (TWA) detection gaining robustness according to trend and single-frequency interferences. They were compared to classic detectors such as matched pairs t test, unpaired t test, spectral method, generalized likelihood ratio test and estimated TWA amplitude within a simulation framework and applied to real data. The optimal detection threshold was selected by using a full Monte-Carlo simulation where signals, with and without alternans episodes, were corrupted by Gaussian noise with different power and single-frequency interferences with different tones. All the combinations of noise and frequency were selected and repeated 500 times in order to compute probability of detection (\(P_{\mathrm{d}}\)) and the false alarm probability (\(P_{\mathrm{fa}}\)), providing ROC curves. The study group consisted of 50 patients with implantable cardioverter-defibrillator (age: \(55.3 \pm 16.4\); LVEF: \(42.8 \pm 15.5\)), who were paced (ventricular pacing) at 100 bpm. Two-minute recordings were analyzed. The XYZ orthogonal lead system was used. The best performance was reached by using the modified matched pairs t test (in comparison with the spectral method and other reference methods).


T-wave alternans Detector Electrocardiography Ventricular arrhythmia 



This work was partially supported by the research project DEC-2011/01/B/ST7/06801 of the Polish National Science Centre.


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Copyright information

© International Federation for Medical and Biological Engineering 2015

Authors and Affiliations

  • O. Meste
    • 1
  • D. Janusek
    • 2
  • S. Karczmarewicz
    • 3
  • A. Przybylski
    • 4
  • M. Kania
    • 2
  • A. Maciag
    • 4
  • R. Maniewski
    • 2
  1. 1.Laboratoire I3S UNS-CNRS UMR7172Université de Nice-Sophia AntipolisSophia Antipolis CedexFrance
  2. 2.Nalecz Institute of Biocybernetics and Biomedical Engineering PASWarsawPoland
  3. 3.Warsaw Education Center CVG Medtronic PolandWarsawPoland
  4. 4.Cardiac Arrhythmias DepartmentNational Institute of CardiologyWarsawPoland

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