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Space–time network connectivity and cortical activations preceding spike wave discharges in human absence epilepsy: a MEG study

  • Disha Gupta
  • Pauly OssenblokEmail author
  • Gilles van Luijtelaar
Special Issue - Original Article

Abstract

To describe the spatial and temporal profiles of connectivity networks and sources preceding generalized spike-and-wave discharges (SWDs) in human absence epilepsy. Nonlinear associations of MEG signals and cluster indices obtained within the framework of graph theory were determined, while source localization in the frequency domain was performed in the low frequency bands with dynamic imaging of coherent sources. The results were projected on a three-dimensional surface rendering of the brain using a semi-realistic head model and MRI images obtained for each of the five patients studied. An increase in clustering and a decrease in path length preceding SWD onset and a rhythmic pattern of increasing and decreasing connectivity were seen during SWDs. Beamforming showed a consistent appearance of a low frequency frontal cortical source prior to the first generalized spikes. This source was preceded by a low frequency occipital source. The changes in the connectivity networks with the onset of SWDs suggest a pathologically predisposed state towards synchronous seizure networks with increasing connectivity from interictal to preictal and ictal state, while the occipital and frontal low frequency early preictal sources demonstrate that SWDs are not suddenly arising but gradually build up in a dynamic network.

Keywords

Spike wave discharge Absence epilepsy Nonlinear association analysis Beamforming Magnetoencephalography Connectivity Small world networks 

Notes

Acknowledgments

This study was funded by the Netherlands Organization for Scientific Research (NWO), Grant number 400-04-483 to GvL and PO. We would like to thank Prof. Dr. P. Fries and co-workers for their hospitality at the Donders Center for Neuroimaging, Nijmegen, the Netherlands.

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Copyright information

© International Federation for Medical and Biological Engineering 2011

Authors and Affiliations

  • Disha Gupta
    • 1
  • Pauly Ossenblok
    • 2
    Email author
  • Gilles van Luijtelaar
    • 1
  1. 1.Donders Centre for Cognition, Institute for Brain Cognition and BehaviourRadboud University NijmegenNijmegenThe Netherlands
  2. 2.Department of Clinical PhysicsEpilepsy Center KempenhaegheHeezeThe Netherlands

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