This paper presents an application of functional principal component analysis (FPCA) to describe the inter-subject variability of multiple waveforms. This technique was applied to the study of sit-to-stand movement in two groups of people, osteoarthritic patients and healthy subjects. Although STS movement has not been extensively applied to the study of knee osteoarthritis, it can provide relevant information about the effect of osteoarthritis on knee joint function. Two waveforms, knee flexion angle and flexion moment, were analysed simultaneously. Instead of using the common multivariate approach we used the functional one, which allows working with continuous functions with neither discretization nor time-scale normalization. The results show that time-scale normalization can alter the FPCA solution. Furthermore, FPCA presents better discriminatory power compared with the classical multivariate approach. This technique can, therefore, be applied as a functional assessment tool, allowing the identification of relevant variables to discriminate heterogeneous groups such as healthy and pathological subjects.
Functional assessment Sit-to-stand movement Functional data Principal component analysis
This study has been partially supported by Spanish Government Grant DPI2006-14722-C02-01 (cofinanced by EU FEDER funds), CICYT MTM2005-08689-C02-02, TIN2006-10134 and Fundació Caixa Castelló P11B2004-15.
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