Medical & Biological Engineering & Computing

, Volume 46, Issue 1, pp 61–67 | Cite as

A new method of screening for diabetic neuropathy using laser Doppler and photoplethysmography

  • Sung Woo Kim
  • Soo Chan Kim
  • Ki Chang Nam
  • Eun Seok Kang
  • Jae Jung Im
  • Deok Won Kim
Original Article


The purpose of this study is to suggest a simple, new method of screening for diabetic neuropathy. We measured blood volume changes by photoplethysmography (PPG) and blood perfusion by laser Doppler (LD) in the index fingers and big toes in 40 control subjects and in 50 (19 mild, 17 moderate, and 14 severe based on the nerve conduction velocity (NCV) test) and 35 diabetic patients with and without neuropathy, respectively. According to the results of PPG and LD measurements, the toe to finger ratios obtained from the neuropathic group were significantly higher than those from the control (p < 0.001) and the non-neuropathic groups (p < 0.001). Based on the NCV, the sensitivity of the LD method (92.0%) was higher than that of the PPG method (84.0%) for both left and right sides. Although specificity of the LD (92.8%) was also higher than the PPG (84.3%) bilaterally, the PPG showed better reproducibility (5.5 versus 9.5%) and a significant ratio increase with severity, while the LD did not. Our suggested PPG method using the toe to finger ratio is reliable, simple, economical, and accurate, and could become an effective new screening tool for the early detection of diabetic neuropathy.


Diabetic neuropathy Photoplethysmography Laser Doppler Blood volume change Toe to finger ratio 


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Copyright information

© International Federation for Medical and Biological Engineering 2007

Authors and Affiliations

  • Sung Woo Kim
    • 1
  • Soo Chan Kim
    • 2
  • Ki Chang Nam
    • 3
  • Eun Seok Kang
    • 4
  • Jae Jung Im
    • 5
  • Deok Won Kim
    • 1
  1. 1.Department of Medical Engineering, College of MedicineYonsei UniversitySeoulSouth Korea
  2. 2.Graduate School of Bio and Information TechnologyHankyong National UniversityAnseongSouth Korea
  3. 3.National Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan
  4. 4.Division of Endocrinology and Metabolism, Department of Internal Medicine, College of MedicineYonsei UniversitySeoulSouth Korea
  5. 5.Division of Electronics and Information EngineeringChonbuk National UniversityChonjuSouth Korea

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