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Closed-loop control of the heart rate by electrical stimulation of the vagus nerve

  • Marco Tosato
  • Ken Yoshida
  • Egon Toft
  • Vitas Nekrasas
  • Johannes J. Struijk
ORIGINAL ARTICLE

Abstract

Stimulation of the vagus nerve potentially decreases the risk of sudden cardiac death. An improvement of the technique would be its regulation using the heart rate (HR) as a feedback variable. We address the possibility of closed-loop control of the HR, focusing on the stimulation parameters, nerve fibre populations and the reproducibility of the cardiovascular response. The response to electrical stimulation of the vagus nerve was studied in seven acute experiments on pigs. Feedback regulation of the HR over periods of 5 min was carried out. Three main populations of myelinated fibres were found. The performance of the controller was significantly better at amplitudes higher than those needed for stimulation of the myelinated components only. A 18% change in the duration of the RR interval could be controlled in all experiments. The possibility of closed-loop control of the HR seems to be promising.

Keywords

Vagus nerve Vagal compound action potential Electrical stimulation Heart rate Closed-loop control 

Notes

Acknowledgements

The authors thank Dr Henrik Barlebo for access to the Biolab and helping to make this study possible. We also thank Ole Sørensen, Torben Madsen and Jens Sørensen, for their useful technical suggestions and help in handling the animals. This work was supported by the European Commission for the NeuralPRO Network (FP5-Program, Research and Training Network).

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Copyright information

© International Federation for Medical and Biological Engineering 2006

Authors and Affiliations

  • Marco Tosato
    • 1
  • Ken Yoshida
    • 1
  • Egon Toft
    • 1
    • 2
  • Vitas Nekrasas
    • 3
  • Johannes J. Struijk
    • 1
  1. 1.Center for Sensory-Motor Interaction (SMI), Department of Health Science and TechnologyAalborg UniversityAalborg EastDenmark
  2. 2.Department of Cardiology, Aalborg Hospital Aarhus University HospitalAalborgDenmark
  3. 3.Department of Thoracic Surgery, Aalborg HospitalAarhus University HospitalAalborgDenmark

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