Frontiers in Biology

, Volume 8, Issue 4, pp 369–376 | Cite as

The perinucleolar compartment associates with malignancy

  • Yiping Wen
  • Chen Wang
  • Sui HuangEmail author


The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.


PNC cancer nuclear substructure gene expression regulation structure and function 


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Cell and Molecular BiologyNorthwestern University, Feinberg School of MedicineChicagoUSA
  2. 2.College of Veterinary MedicineSichuan Agricultural UniversityYaanChina

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