Frontiers in Biology

, Volume 8, Issue 1, pp 1–31 | Cite as

DISC1 genetics, biology and psychiatric illness

  • Pippa A. Thomson
  • Elise L.V. Malavasi
  • Ellen Grünewald
  • Dinesh C. Soares
  • Malgorzata Borkowska
  • J. Kirsty MillarEmail author


Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points toward DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.


DISC1 schizophrenia depression genetics neural pathways 


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Pippa A. Thomson
    • 1
  • Elise L.V. Malavasi
    • 1
  • Ellen Grünewald
    • 1
    • 2
  • Dinesh C. Soares
    • 1
  • Malgorzata Borkowska
    • 3
  • J. Kirsty Millar
    • 1
    Email author
  1. 1.The Centre for Molecular Medicine at the Medical Research Council Institute of Genetics and Molecular MedicineThe University of Edinburgh, Western General HospitalEdinburghUK
  2. 2.Division of PsychiatryThe University of Edinburgh, Royal Edinburgh HospitalEdinburghUK
  3. 3.Centre for Integrative PhysiologyThe University of EdinburghEdinburghUK

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