Applied Research in Quality of Life

, Volume 9, Issue 1, pp 99–112 | Cite as

Illness Perception Mediates the Effect of Illness Course on the Quality of Life of Mexican Patients with Psychosis

  • Lizzette Gómez-de-Regil
  • Thomas R. Kwapil
  • Neus Barrantes-Vidal


Learning about possible factors influencing, positively or negatively, the Quality of Life (QoL) of patients with psychosis is an important task for both, research and treatment. The study examined the association of illness course with QoL in a sample of Mexican patients with psychosis. It was hypothesized that illness perception would mediate the relation of illness course to QoL. Sixty-one (56 % female) patients were interviewed and assessed for illness course (relapses, residual symptoms, and diagnosis), QoL, and illness perception. Mediation analyses (simple and multiple) with bootstrapping procedures were applied, including residual symptoms as the predictor of QoL, and illness perception dimensions as candidate mediators. Residual symptoms, rather than a relapsing course or a diagnosis of schizophrenia, have a diminishing effect in the subjective QoL. This effect is fully mediated by illness perception, particularly by the cognitive and the emotional representations. Results underscore the importance that patients’ beliefs have on their perceived QoL, encouraging further research and development of interventions targeting illness perceptions.


Psychosis Illness perception Quality of life Illness course Mexican 



LGR thanks the Consejo Nacional de Ciencia y Tecnología (CONACyT), Mexico, for funding number 187498. NBV and TRK are supported by the Spanish Ministry of Science and Innovation (PSI2008-04178), the Generalitat de Catalunya, Suport als Grups de Recerca (SGR2009672), and La Fundació La Marató de TV3 (091110). We thank the Hospital Psiquiátrico Yucatán (México) for its support and all who kindly took part as participants.

Conflict of interest

All authors declare that they have no conflicts of interest.


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Copyright information

© Springer Science+Business Media Dordrecht and The International Society for Quality-of-Life Studies (ISQOLS) 2013

Authors and Affiliations

  • Lizzette Gómez-de-Regil
    • 1
    • 2
  • Thomas R. Kwapil
    • 3
  • Neus Barrantes-Vidal
    • 4
    • 5
    • 6
    • 7
  1. 1.Hospital Regional de Alta Especialidad de la Península de Yucatán, Departamento de Planeación, Enseñanza e InvestigaciónMéridaMéxico
  2. 2.Universitat Autònoma de BarcelonaBellaterraSpain
  3. 3.Department of PsychologyUniversity of North Carolina at GreensboroGreensboroUSA
  4. 4.Departament de Psicologia Clínica i de la SalutUniversitat Autònoma de BarcelonaBellaterraSpain
  5. 5.Sant Pere Claver - Fundació SanitàriaBarcelonaSpain
  6. 6.Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)MadridSpain
  7. 7.University of North Carolina at GreensboroGreensboroUSA

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