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Journal of Neuroimmune Pharmacology

, Volume 13, Issue 3, pp 277–278 | Cite as

Pneumocystis Pneumonia during Rituximab Treatment in Children with Autoimmune Nerve System Diseases

  • Ji Zhou
  • Yao Zhang
  • Yiwen Jin
  • Taoyun Ji
  • Xinhua Bao
  • Yuehua Zhang
  • Hui Xiong
  • Xinzhi Chang
  • Yuwu Jiang
  • Ye Wu
LETTER TO THE EDITOR
  • 59 Downloads

Dear Editor:

Rituximab is an anti-CD20 monoclonal antibody which eliminates B lymphocytes in peripheral blood. Pneumocystis pneumonia is an opportunistic infection caused by pneumocystis jirovecii. Defect in cell-mediated immunity is the primary cause of pneumocystis pneumonia. Some studies have reported occurrence of pneumocystis pneumonia after rituximab use in cancer, hematopoietic cells transplantation and systemic rheumatologic diseases. Thus far, only one case suffering from pneumocystis pneumonia during treatment autoimmune nervous system disease with rituximab was reported. This patient was treated concurrently with high doses of corticosteroid and cyclophosphamide (Garcia-Moreno et al. 2016). Thus, whether pneumocystis pneumonia was related with rituximab was unclear.

In pediatric neurological department of Peking University First Hospital, a total of 79 paediatric patients were diagnosed with nervous system autoimmune diseases and treated with rituximab with follow-up median...

Notes

Acknowledgements

We thank Prof. Russell C. Dale of the Children’s Hospital at Westmead, University of Sydney for the great ideas in this study and the revision for this paper.

Compliance with Ethical Standards

Ethical Approval

The study was approved by the Ethics Committee of the Peking University First Hospital.

Informed Consent

Patients were gave written informed consent.

Conflict of Interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ji Zhou
    • 1
  • Yao Zhang
    • 1
  • Yiwen Jin
    • 1
  • Taoyun Ji
    • 1
  • Xinhua Bao
    • 1
  • Yuehua Zhang
    • 1
  • Hui Xiong
    • 1
  • Xinzhi Chang
    • 1
  • Yuwu Jiang
    • 1
  • Ye Wu
    • 1
  1. 1.Department of PediatricsPeking University First HospitalBeijingChina

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