Abstracts from the Joint Meeting of the International Society for NeuroVirology (ISNV) and the Society on NeuroImmune Pharmacology (SNIP) April 10-14, 2018, Chicago, Illinois, USA
TIMBD modulates neurotransmission and improves HIV-1 Tat-associated anxiety-like behavior and memory deficits in Tat-transgenic mice
Fatma Abdalla, Hari K. Bhat, Anil Kumar
(corresponding author: firstname.lastname@example.org)
Department of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City
HIV-1 Tat has been implicated in Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND). Patients with HAND suffer from both cognitive and motor dysfunction which is characterized by memory loss and changes in personality. A variety of natural products including resveratrol (RES) have been tried as interventional agents to improve neurocognition. Resveratrol is one of the known phytoestrogens with potential antioxidant and anti-inflammatory properties that has been tested for its inhibitory effects in neurodegeneration. However studies suggests RES’s poor specificity and bioavailability as a reason for its poor efficacy. To overcome these problems...