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Journal of Neuroimmune Pharmacology

, Volume 12, Issue 3, pp 531–543 | Cite as

Systemic Inflammation during the First Postnatal Month and the Risk of Attention Deficit Hyperactivity Disorder Characteristics among 10 year-old Children Born Extremely Preterm

  • Elizabeth N. Allred
  • Olaf Dammann
  • Raina N. Fichorova
  • Stephen R Hooper
  • Scott J Hunter
  • Robert M. Joseph
  • Karl Kuban
  • Alan LevitonEmail author
  • Thomas Michael O’Shea
  • Megan N. Scott
  • The ELGAN Study ADHD symptoms writing group for the ELGAN Study Investigators
ORIGINAL ARTICLE

Abstract

Although multiple sources link inflammation with attention difficulties, the only human study that evaluated the relationship between systemic inflammation and attention problems assessed attention at age 2 years. Parent and/or teacher completion of the Childhood Symptom Inventory-4 (CSI-4) provided information about characteristics that screen for attention deficit hyperactive disorder (ADHD) among 793 10-year-old children born before the 28th week of gestation who had an IQ ≥ 70. The concentrations of 27 proteins in blood spots obtained during the first postnatal month were measured. 151 children with ADHD behaviors were identified by parent report, while 128 children were identified by teacher report. Top-quartile concentrations of IL-6R, TNF-α, IL-8, VEGF, VEFG-R1, and VEGF-R2 on multiple days were associated with increased risk of ADHD symptoms as assessed by a teacher. Some of this increased risk was modulated by top-quartile concentrations of IL-6R, RANTES, EPO, NT-4, BDNF, bFGF, IGF-1, PIGF, Ang-1, and Ang-2. Systemic inflammation during the first postnatal month among children born extremely preterm appears to increase the risk of teacher-identified ADHD characteristics, and high concentrations of proteins with neurotrophic properties appear capable of modulating this increased risk.

Keywords

Infant, premature/blood Attention deficit hyperactivity disorder Inflammation Neuroprotection 

Notes

Acknowledgements

This study was supported by The National Institute of Neurological Disorders and Stroke (5U01NS040069-05; 2R01NS040069-06A2), The National Eye Institute (1-R01-EY021820-01), and the National Institute of Child Health and Human Development (5P30HD018655-34).

The authors gratefully acknowledge the contributions of their subjects and their subjects’ families, as well as the contributions of their colleagues.

Participating Institutions and ELGAN Study Collaborators Who Made this Report Possible

Baystate Medical Center, Springfield MA (Bhavesh Shah, Karen Christianson)

Beth Israel Deaconess Medical Center, Boston MA (Camilia R. Martin, Colleen Hallisey, Caitlin Hurley, Miren Creixell)

Brigham & Women’s Hospital, Boston MA (Linda J. Van Marter)

Boston Children’s Hospital, Boston MA (Alan Leviton, Kathleen Lee, Anne McGovern, Elizabeth Allred, Jill Gambardella, Susan Ursprung, Ruth Blomquist)

Massachusetts General Hospital, Boston MA (Robert Insoft, Jennifer G. Wilson, Maureen Pimental)

New England Medical Center, Boston MA (Cynthia Cole, John Fiascone, Janet Madden, Ellen Nylen, Anne Furey)

U Mass Memorial Health Center, Worcester, MA (Francis Bednarek [deceased], Mary Naples, Beth Powers)

Yale-New Haven Hospital, New Haven CT (Richard Ehrenkranz, Joanne Williams, Elaine Romano)

Forsyth Hospital, Baptist Medical Center, Winston-Salem NC (T. Michael O’Shea, Debbie Gordon, Teresa Harold, Gail Hounsell, Debbie Hiatt)

University Health Systems of Eastern Carolina, Greenville NC (Stephen Engelke, Sherry Moseley, Linda Pare, Donna Smart, Joan Wilson)

North Carolina Children’s Hospital, Chapel Hill NC (Carl Bose, Gennie Bose, Janice Wereszczak)

DeVos Children’s Hospital, Grand Rapids MI (Mariel Portenga, Dinah Sutton)

Sparrow Hospital, Lansing MI (Padmani Karna, Carolyn Solomon)

University of Chicago Hospital, Chicago IL (Michael D. Schreiber, Grace Yoon)

William Beaumont Hospital, Royal Oak MI (Daniel Batton, Beth Kring)

Compliance with Ethical Standards

Conflict of Interest Statement

The authors report no conflict of interest, financial or otherwise.

Supplementary material

11481_2017_9742_MOESM1_ESM.docx (110 kb)
ESM 1 (DOCX 109 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Elizabeth N. Allred
    • 1
  • Olaf Dammann
    • 2
  • Raina N. Fichorova
    • 3
  • Stephen R Hooper
    • 4
  • Scott J Hunter
    • 5
  • Robert M. Joseph
    • 6
  • Karl Kuban
    • 7
  • Alan Leviton
    • 1
    Email author
  • Thomas Michael O’Shea
    • 4
  • Megan N. Scott
    • 5
  • The ELGAN Study ADHD symptoms writing group for the ELGAN Study Investigators
  1. 1.Boston Children’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Tufts University School of MedicineBostonUSA
  3. 3.Brigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  4. 4.University of North Carolina School of MedicineChapel HillUSA
  5. 5.The University of Chicago Medicine Comer Children’s HospitalChicagoUSA
  6. 6.Boston University School of MedicineBostonUSA
  7. 7.Boston Medical Center and Boston University School of MedicineBostonUSA

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