Journal of Neuroimmune Pharmacology

, Volume 12, Issue 3, pp 389–401 | Cite as

Chronic Tobacco-Smoking on Psychopathological Symptoms, Impulsivity and Cognitive Deficits in HIV-Infected Individuals

ORIGINAL ARTICLE
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Abstract

HIV-infected individuals (HIV+) has 2–3 times the rate of tobacco smoking than the general population, and whether smoking may lead to greater psychiatric symptoms or cognitive deficits remains unclear. We evaluated the independent and combined effects of being HIV+ and chronic tobacco-smoking on impulsivity, psychopathological symptoms and cognition. 104 participants [27 seronegative (SN)-non-Smokers, 26 SN-Smokers, 29 HIV+ non-Smokers, 22 HIV+ Smokers] were assessed for psychopathology symptoms (Symptom Checklist-90, SCL-90), depressive symptoms (Center for Epidemiologic Studies-Depression Scale, CES-D), impulsivity (Barratt Impulsiveness Scale, BIS), decision-making (The Iowa Gambling Task, IGT, and Wisconsin Card Sorting Test, WCST), and cognition (seven neurocognitive domains). Both HIV+ and Smoker groups had higher SCL-90 and CES-D scores, with highest scores in HIV+ Smokers. On BIS, both HIV+ and Smokers had higher Total Impulsiveness scores, with higher behavioral impulsivity in Smokers, highest in HIV+ Smokers. Furthermore, across the four groups, HIV+ Smokers lost most money and made fewest advantageous choices on the IGT, and had highest percent errors on WCST. Lastly, HIV+ had lower z-scores on all cognitive domains, with the lowest scores in HIV+ Smokers. These findings suggest that HIV-infection and chronic tobacco smoking may lead to additive deleterious effects on impulsivity, psychopathological (especially depressive) symptoms and cognitive dysfunction. Although greater impulsivity may be premorbid in HIV+ and Smokers, the lack of benefits of nicotine in chronic Smokers on attention and psychopathology, especially those with HIV-infection, may be due to the negative effects of chronic smoking on dopaminergic and cardio-neurovascular systems. Tobacco smoking may contribute to psychopathology and neurocognitive disorders in HIV+ individuals.

Keywords

HIV Tobacco use Decision making Risk Psychopathology 

Notes

Acknowledgments

This work was supported by the National Institutes of Health grants (2 K24-DA16170; U54-NS56883; G12 MD007601). We are grateful to our research participants and the referral physicians from our community providers, including Dr. Drew Kovach, Dr. Dominic Chow, Dr. Jennifer Frank, Dr. Cyril Goshima, and the personnel at the Life Foundation, the Gregory House and at Save the Food Basket. We also appreciate the meticulous and hard work from the multiple clinical and technical research staff members (especially Mark Lum, B.S.) who assisted in the data collection of this study.

Compliance with Ethical Standards

Conflict of Interest Statement

The authors have declared that no conflict of interest exists.

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© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Neuroscience & MR Research Program, Department of Medicine, John A. Burns School of MedicineUniversity of Hawaii and Queen’s Medical CenterHonoluluUSA

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