Commentary on Special Issue: CNS Diseases and the Immune System
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In an increasing number of central nervous system (CNS) diseases a pathogenic contribution of the immune system is proposed. However, the exact underlying mechanisms are often poorly understood. The collection of articles in this special issue presents a state-of-the-art review of adaptive and innate immune mechanisms and their main players in number CNS disorders. The aim of these articles is to stimulate discussion on the question whether the immune system may be a feasible target of therapy for diseases where currently no effective treatment exists.
KeywordsNeuroinflammation Neurodegeneration Adaptive immunity Innate immunity
Conflict of interest
The authors report no conflict of interest.
- Gabibov AG, Belogurov AA Jr, Lomakin YA, Zakharova MY, Avakyan ME, Dubrovskaya VV, Smirnov IV, Ivanov AS, Molnar AA, Gurtsevitch VE, Diduk SV, Smirnova KV, Avalle B, Sharanova SN, Tramontano A, Friboulet A, Boyko AN, Ponomarenko NA, Tikunova NV (2011) Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen. FASEB J 25:4211–4221PubMedCrossRefGoogle Scholar
- ‘t Hart BA, Abbott DH, Nakamura K, Fuchs E (2012) The marmoset monkey: a multi-purpose preclinical and translational model of human biology and disease. Drug Discov Today 17(21–22):1160-1165Google Scholar
- ‘t Hart BA, Jagessar SA, Haanstra K, Verschoor E, Laman JD, Kap YS (2013) The primate EAE model points at EBV-infected B cells as a preferential therapy target in multiple sclerosis. Front Immunol in pressGoogle Scholar