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Journal of Neuroimmune Pharmacology

, Volume 5, Issue 3, pp 428–442 | Cite as

Arboviral Encephalitides: Transmission, Emergence, and Pathogenesis

  • Bradley S. Hollidge
  • Francisco González-Scarano
  • Samantha S. SoldanEmail author
INVITED REVIEW

Abstract

Arthropod-borne viruses (arboviruses) are of paramount concern as a group of pathogens at the forefront of emerging and re-emerging diseases. Although some arboviral infections are asymptomatic or present with a mild influenza-like illness, many are important human and veterinary pathogens causing serious illness ranging from rash and arthritis to encephalitis and hemorrhagic fever. Here, we discuss arboviruses from diverse families (Flaviviruses, Alphaviruses, and the Bunyaviridae) that are causative agents of encephalitis in humans. An understanding of the natural history of these infections as well as shared mechanisms of neuroinvasion and neurovirulence is critical to control the spread of these viruses and for the development of effective vaccines and treatment modalities.

Keywords

arbovirus Flavivirus Bunyaviridae Alphavirus encephalitis 

Notes

Acknowledgments and statement regarding conflicts of interest

This work was supported by PHS grants 1R01AI074626-01 and T32-NS07180. The authors declare that there are no conflicts of interest.

References

  1. Outbreak of Rift Valley fever—Saudi Arabia, August–October 2000. MMWR Morb Mortal Wkly Rep, 49, 905–908.Google Scholar
  2. Abd el-Rahim IH, Abd el-Hakim U, Hussein M (1999) An epizootic of Rift Valley fever in Egypt in 1997. Rev Sci Tech 18:741–748PubMedGoogle Scholar
  3. Abu-Elyazeed R, El-Sharkawy S, Olson J, Botros B, Soliman A, Salib A, Cummings C, Arthur R (1996) Prevalence of anti-Rift-Valley-fever IgM anitbody in abattoir workers in the Nile delta during the 1993 outbreak in Egypt. Bull World Health Organ 74:155–158PubMedGoogle Scholar
  4. Angelini P, Macini P, Finarelli AC, Pol C, Venturelli C, Bellini R, Dottori M (2008) Chikungunya epidemic outbreak in Emilia-Romagna (Italy) during summer 2007. Parassitologia 50:97–98PubMedGoogle Scholar
  5. Arthur RR, El-Sharkawy MS, Cope SE, Botros BA, Oun S, Morrill JC, Shope RE, Hibbs RG, Darwish MA, Imam IZ (1993) Recurrence of Rift Valley fever in Egypt. Lancet 342:1149–1150PubMedCrossRefGoogle Scholar
  6. Babu GN, Kalita J, Misra UK (2006) Inflammatory markers in the patients of Japanese encephalitis. Neurol Res 28:190–192PubMedCrossRefGoogle Scholar
  7. Balkhy HH, Memish ZA (2003) Rift Valley fever: an uninvited zoonosis in the Arabian peninsula. Int J Antimicrob Agents 21:153–157PubMedCrossRefGoogle Scholar
  8. Barrett AD, Higgs S (2007) Yellow fever: a disease that has yet to be conquered. Annu Rev Entomol 52:209–229PubMedCrossRefGoogle Scholar
  9. Benedict MQ, Levine RS, Hawley WA, Lounibos LP (2007) Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus. Vector Borne Zoonotic Dis 7:76–85PubMedCrossRefGoogle Scholar
  10. Billecocq A, Spiegel M, Vialat P, Kohl A, Weber F, Bouloy M, Haller O (2004) NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J Virol 78:9798–9806PubMedCrossRefGoogle Scholar
  11. Billoir F, De Chesse R, Tolou H, De Micco P, Gould EA, De Lamballerie X (2000) Phylogeny of the genus flavivirus using complete coding sequences of arthropod-borne viruses and viruses with no known vector. J Gen Virol 81:781–790PubMedGoogle Scholar
  12. Bird BH, Ksiazek TG, Nichol ST, Maclachlan NJ (2009) Rift Valley fever virus. J Am Vet Med Assoc 234:883–893PubMedCrossRefGoogle Scholar
  13. Blakqori G, Delhaye S, Habjan M, Blair CD, Sanchez-Vargas I, Olson KE, Attarzadeh-Yazdi G, Fragkoudis R, Kohl A, Kalinke U, Weiss S, Michiels T, Staeheli P, Weber F (2007) La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol 81:4991–4999PubMedCrossRefGoogle Scholar
  14. Borucki MK, Kempf BJ, Blitvich BJ, Blair CD, Beaty BJ (2002) La Crosse virus: replication in vertebrate and invertebrate hosts. Microbes Infect 4:341–350PubMedCrossRefGoogle Scholar
  15. Brault AC, Powers AM, Holmes EC, Woelk CH, Weaver SC (2002) Positively charged amino acid substitutions in the e2 envelope glycoprotein are associated with the emergence of venezuelan equine encephalitis virus. J Virol 76:1718–1730PubMedCrossRefGoogle Scholar
  16. Briese T, Jia XY, Huang C, Grady LJ, Lipkin WI (1999) Identification of a Kunjin/West Nile-like flavivirus in brains of patients with New York encephalitis. Lancet 354:1261–1262PubMedCrossRefGoogle Scholar
  17. Brinton MA (2002) The molecular biology of West Nile Virus: a new invader of the western hemisphere. Annu Rev Microbiol 56:371–402PubMedCrossRefGoogle Scholar
  18. Broom AK, Lindsay MD, Plant AJ, Wright AE, Condon RJ, Mackenzie JS (2002) Epizootic activity of Murray Valley encephalitis virus in an aboriginal community in the southeast Kimberley region of Western Australia: results of cross-sectional and longitudinal serologic studies. Am J Trop Med Hyg 67:319–323PubMedGoogle Scholar
  19. Burke DS, Nisalak A, Ussery MA, Laorakpongse T, Chantavibul S (1985) Kinetics of IgM and IgG responses to Japanese encephalitis virus in human serum and cerebrospinal fluid. J Infect Dis 151:1093–1099PubMedGoogle Scholar
  20. Calisher CH (1986) History, Classification, and Taxonomy of Viruses in the Family Bunyaviridae. In: Elliot R (ed) The Bunyaviridae. Plenum Press, New YorkGoogle Scholar
  21. Cao M, Feng Z, Zhang J, Ma J, Li X (2010) Contextual risk factors for regional distribution of Japanese encephalitis in the People’s Republic of China. Trop Med Int Health (in press)Google Scholar
  22. Caplen H, Peters CJ, Bishop DH (1985) Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development. J Gen Virol 66(Pt 10):2271–2277PubMedCrossRefGoogle Scholar
  23. Cassidy LF, Patterson JL (1989) Mechanism of La Crosse virus inhibition by ribavirin. Antimicrob Agents Chemother 33:2009–2011PubMedGoogle Scholar
  24. Cavrini F, Gaibani P, Pierro AM, Rossini G, Landini MP, Sambri V (2009) Chikungunya: an emerging and spreading arthropod-borne viral disease. J Infect Dev Ctries 3:744–752PubMedGoogle Scholar
  25. CDC (2005) Fact Sheet: Western Equine Encephalitis.Google Scholar
  26. CDC (2010) Eastern Equine Encephalitis.Google Scholar
  27. Charles PC, Walters E, Margolis F, Johnston RE (1995) Mechanism of neuroinvasion of Venezuelan equine encephalitis virus in the mouse. Virology 208:662–671PubMedCrossRefGoogle Scholar
  28. Colon-Ramos DA, Irusta PM, Gan EC, Olson MR, Song J, Morimoto RI, Elliott RM, Lombard M, Hollingsworth R, Hardwick JM, Smith GK, Kornbluth S (2003) Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell 14:4162–4172PubMedCrossRefGoogle Scholar
  29. Couderc T, Chretien F, Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Cayet N, Schuffenecker I, Despres P, Arenzana-Seisdedos F, Michault A, Albert ML, Lecuit M (2008) A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog 4:e29PubMedCrossRefGoogle Scholar
  30. Daubney R, Hudson JR (1931) Enzootic hepatitis or Rift Valley fever: an undescribed virus disease of sheep cattle and man from east Africa. J Path Bacteriol 34:545–579CrossRefGoogle Scholar
  31. Davis LE, Debiasi R, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, Demasters BK, Tyler KL (2006) West Nile virus neuroinvasive disease. Ann Neurol 60:286–300PubMedCrossRefGoogle Scholar
  32. Day JF (2001) Predicting St. Louis encephalitis virus epidemics: lessons from recent, and not so recent, outbreaks. Annu Rev Entomol 46:111–138PubMedCrossRefGoogle Scholar
  33. Diamond MS (2009) Virus and host determinants of West Nile virus pathogenesis. PLoS Pathog 5:e1000452PubMedCrossRefGoogle Scholar
  34. Dionisio D, Esperti F, Vivarelli A, Valassina M (2003) Epidemiological, clinical and laboratory aspects of sandfly fever. Curr Opin Infect Dis 16:383–388PubMedCrossRefGoogle Scholar
  35. Duggan ST, Plosker GL (2009) Japanese encephalitis vaccine (inactivated, adsorbed) [IXIARO]. Drugs 69:115–122PubMedCrossRefGoogle Scholar
  36. Dutta K, Ghosh D, Basu A (2009) Curcumin protects neuronal cells from Japanese encephalitis virus-mediated cell death and also inhibits infective viral particle formation by dysregulation of ubiquitin-proteasome system. J Neuroimmune Pharmacol 4:328–337PubMedCrossRefGoogle Scholar
  37. Elliott RM (2009) Bunyaviruses and climate change. Clin Microbiol Infect 15:510–517PubMedCrossRefGoogle Scholar
  38. Ergonul O (2006) Crimean-Congo haemorrhagic fever. Lancet Infect Dis 6:203–214PubMedCrossRefGoogle Scholar
  39. Fischer M, Lindsey N, Staples JE, Hills S (2010) Japanese encephalitis vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 59:1–27Google Scholar
  40. Fonseca DM, Keyghobadi N, Malcolm CA, Mehmet C, Schaffner F, Mogi M, Fleischer RC, Wilkerson RC (2004) Emerging vectors in the Culex pipiens complex. Science 303:1535–1538PubMedCrossRefGoogle Scholar
  41. Fontenille D, Traore-Lamizana M, Diallo M, Thonnon J, Digoutte JP, Zeller HG (1998) New vectors of Rift Valley fever in West Africa. Emerg Infect Dis 4:289–293PubMedCrossRefGoogle Scholar
  42. Gao X, Nasci R, Liang G (2010) The neglected arboviral infections in mainland China. PLoS Negl Trop Dis 4:e624PubMedCrossRefGoogle Scholar
  43. Gauld LW, Hanson RP, Thompson WH, Sinha SK (1974) Observations on a natural cycle of La Crosse virus (California group) in Southwestern Wisconsin. Am J Trop Med Hyg 23:983–992PubMedGoogle Scholar
  44. Gerhardt RR, Gottfried KL, Apperson CS, Davis BS, Erwin PC, Smith AB, Panella NA, Powell EE, Nasci RS (2001) First isolation of La Crosse virus from naturally infected Aedes albopictus. Emerg Infect Dis 7:807–811PubMedCrossRefGoogle Scholar
  45. Glass WG, Mcdermott DH, Lim JK, Lekhong S, Yu SF, Frank WA, Pape J, Cheshier RC, Murphy PM (2006) CCR5 deficiency increases risk of symptomatic West Nile virus infection. J Exp Med 203:35–40PubMedCrossRefGoogle Scholar
  46. Gonzalez-Scarano F, Janssen RS, Najjar JA, Pobjecky N, Nathanson N (1985) An avirulent G1 glycoprotein variant of La Crosse bunyavirus with defective fusion function. J Virol 54:757–763PubMedGoogle Scholar
  47. Gonzalez-Scarano F, Bupp K, Nathanson N (1996) Pathogenesis of diseases caused by viruses of the bunyavirus genus. In: Elliot R (ed) The Bunyaviridae. Plenum Press, New YorkGoogle Scholar
  48. Gould EA, De Lamballerie X, Zanotto PM, Holmes EC (2003) Origins, evolution, and vector/host coadaptations within the genus Flavivirus. Adv Virus Res 59:277–314PubMedCrossRefGoogle Scholar
  49. Griot C, Gonzalez-Scarano F, Nathanson N (1993) Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses. Annu Rev Microbiol 47:117–138PubMedCrossRefGoogle Scholar
  50. Gubler DJ (2002) The global emergence/resurgence of arboviral diseases as public health problems. Arch Med Res 33:330–342PubMedCrossRefGoogle Scholar
  51. Gubler DJ (2007) The continuing spread of West Nile virus in the western hemisphere. Clin Infect Dis 45:1039–1046PubMedCrossRefGoogle Scholar
  52. Gunderson, C. B., Brown, K.L. (1983) Clinical aspects of La Crosse encephalitis: preliminary report. IN C.H. Calisher, W. H. T. (Ed.) California Serogroup Viruses. New York, A.R. Liss, Inc.Google Scholar
  53. Gyure KA (2009) West Nile virus infections. J Neuropathol Exp Neurol 68:1053–1060PubMedCrossRefGoogle Scholar
  54. Haddow AD (2009) The use of oral ribavirin in the management of La Crosse viral infections. Med Hypotheses 72:190–192PubMedCrossRefGoogle Scholar
  55. Haddow AD, Odoi A (2009) The incidence risk, clustering, and clinical presentation of La Crosse virus infections in the eastern United States, 2003-2007. PLoS ONE 4:e6145PubMedCrossRefGoogle Scholar
  56. Haddow AD, Jones CJ, Odoi A (2009) Assessing risk in focal arboviral infections: are we missing the big or little picture? PLoS ONE 4:e6954PubMedCrossRefGoogle Scholar
  57. Hammon WM, Sather GE (1973) Passive immunity for arbovirus infection. I. Artificially induced prophylaxis in man and mouse for Japanese (B) encephalitis. Am J Trop Med Hyg 22:524–534PubMedGoogle Scholar
  58. Harrington T, Kuehnert MJ, Kamel H, Lanciotti RS, Hand S, Currier M, Chamberland ME, Petersen LR, Marfin AA (2003) West Nile virus infection transmitted by blood transfusion. Transfusion 43:1018–1022PubMedCrossRefGoogle Scholar
  59. Hayes EB, Komar N, Nasci RS, Montgomery SP, O'leary DR, Campbell GL (2005) Epidemiology and transmission dynamics of West Nile virus disease. Emerg Infect Dis 11:1167–1173PubMedGoogle Scholar
  60. Heft DE, Walton WE (2008) Effects of the El Nino–Southern Oscillation (ENSO) cycle on mosquito populations in southern California. J Vector Ecol 33:17–29PubMedCrossRefGoogle Scholar
  61. Heinz FX, Collett MS, Purcell RH, Gould EA, Howard CR, Houghton M, Moormann RJM, Rice CM, Thiel HJ (2000) Family Flaviviridae. In: van Regenmortel MH, Fauquet CM, Bishop DHL, Carstens E, Estes MK, Lemon S, Maniloff J, Mayo MA, McGeoch D, Pringle CR, Wickner RB (eds) Virus taxonomy: 7th report of the International Committee for the Taxonomy of Viruses. Academic Press, San Diego, CAGoogle Scholar
  62. Hoogstraal H (1979) The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. J Med Entomol 15:307–417PubMedGoogle Scholar
  63. Ikegami T, Makino S (2009) Rift valley fever vaccines. Vaccine 27(Suppl 4):D69–D72PubMedCrossRefGoogle Scholar
  64. Innis BL (1995) Japanese Encephalitis. In: Porterfield JS (ed) Exotic viral infections. Chapman and Hall, LondonGoogle Scholar
  65. Iwamoto M, Jernigan DB, Guasch A, Trepka MJ, Blackmore CG, Hellinger WC, Pham SM, Zaki S, Lanciotti RS, Lance-Parker SE, Diazgranados CA, Winquist AG, Perlino CA, Wiersma S, Hillyer KL, Goodman JL, Marfin AA, Chamberland ME, Petersen LR (2003) Transmission of West Nile virus from an organ donor to four transplant recipients. N Engl J Med 348:2196–2203PubMedCrossRefGoogle Scholar
  66. Janssen R, Gonzalez-Scarano F, Nathanson N (1984) Mechanisms of bunyavirus virulence. Comparative pathogenesis of a virulent strain of La Crosse and an avirulent strain of Tahyna virus. Lab Invest 50:447–455PubMedGoogle Scholar
  67. Janssen RS, Nathanson N, Endres MJ, Gonzalez-Scarano F (1986) Virulence of La Crosse virus is under polygenic control. J Virol 59:1–7PubMedGoogle Scholar
  68. Jia XY, Briese T, Jordan I, Rambaut A, Chi HC, Mackenzie JS, Hall RA, Scherret J, Lipkin WI (1999) Genetic analysis of West Nile New York 1999 encephalitis virus. Lancet 354:1971–1972PubMedCrossRefGoogle Scholar
  69. Johnson RT, Burke DS, Elwell M, Leake CJ, Nisalak A, Hoke CH, Lorsomrudee W (1985) Japanese encephalitis: immunocytochemical studies of viral antigen and inflammatory cells in fatal cases. Ann Neurol 18:567–573PubMedCrossRefGoogle Scholar
  70. Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, Gittleman JL, Daszak P (2008) Global trends in emerging infectious diseases. Nature 451:990–993PubMedCrossRefGoogle Scholar
  71. Kalfayan B (1983) Pathology of La Crosse virus infection in humans. In: Calisher CH, Thompson WH (eds) California serogroup viruses. Liss, New YorkGoogle Scholar
  72. Kielian M (2006) Class II virus membrane fusion proteins. Virology 344:38–47PubMedCrossRefGoogle Scholar
  73. Klein RS, Diamond MS (2008) Immunological headgear: antiviral immune responses protect against neuroinvasive West Nile virus. Trends Mol Med 14:286–294PubMedCrossRefGoogle Scholar
  74. Komar N (2003) West Nile virus: epidemiology and ecology in North America. Adv Virus Res 61:185–234PubMedCrossRefGoogle Scholar
  75. Kramer LD, Li J, Shi PY (2007) West Nile virus. Lancet Neurol 6:171–181PubMedCrossRefGoogle Scholar
  76. Kumar NP, Joseph R, Kamaraj T, Jambulingam P (2008) A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India. J Gen Virol 89:1945–1948PubMedCrossRefGoogle Scholar
  77. Kurane I, Takasaki T (2000) Immunogenicity and protective efficacy of the current inactivated Japanese encephalitis vaccine against different Japanese encephalitis virus strains. Vaccine 18(Suppl 2):33–35PubMedCrossRefGoogle Scholar
  78. Labadie K, Larcher T, Joubert C, Mannioui A, Delache B, Brochard P, Guigand L, Dubreil L, Lebon P, Verrier B, De Lamballerie X, Suhrbier A, Cherel Y, Le Grand R, Roques P (2010) Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest 120:894–906PubMedCrossRefGoogle Scholar
  79. Levi ME, Quan D, Ho JT, Kleinschmidt-Demasters BK, Tyler KL, Grazia TJ (2010) Impact of rituximab-associated B-cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients. Clin Transplant 24:223–228PubMedCrossRefGoogle Scholar
  80. Li Y, Hou L, Ye J, Liu X, Dan H, Jin M, Chen H, Cao S (2010) Development of a convenient immunochromatographic strip for the diagnosis of infection with Japanese encephalitis virus in swine. J Virol Methods (in press)Google Scholar
  81. Linthicum KJ, Bailey CL, Davies FG, Tucker CJ (1987) Detection of Rift Valley fever viral activity in Kenya by satellite remote sensing imagery. Science 235:1656–1659PubMedCrossRefGoogle Scholar
  82. Linthicum KJ, Anyamba A, Tucker CJ, Kelley PW, Myers MF, Peters CJ (1999) Climate and satellite indicators to forecast Rift Valley fever epidemics in Kenya. Science 285:397–400PubMedCrossRefGoogle Scholar
  83. Liou ML, Hsu CY (1998) Japanese encephalitis virus is transported across the cerebral blood vessels by endocytosis in mouse brain. Cell Tissue Res 293:389–394PubMedCrossRefGoogle Scholar
  84. Lundstrom K (2005) Biology and application of alphaviruses in gene therapy. Gene Ther 12(Suppl 1):S92–S97PubMedCrossRefGoogle Scholar
  85. Mackenzie JS, Gubler DJ, Petersen LR (2004) Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses. Nat Med 10:S98–S109PubMedCrossRefGoogle Scholar
  86. Madani TA, Al-Mazrou YY, Al-Jeffri MH, Mishkhas AA, Al-Rabeah AM, Turkistani AM, Al-Sayed MO, Abodahish AA, Khan AS, Ksiazek TG, Shobokshi O (2003) Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics. Clin Infect Dis 37:1084–1092PubMedCrossRefGoogle Scholar
  87. Malkinson M, Banet C (2002) The role of birds in the ecology of West Nile virus in Europe and Africa. Curr Top Microbiol Immunol 267:309–322PubMedGoogle Scholar
  88. Marfin AA, Gubler DJ (2001) West Nile encephalitis: an emerging disease in the United States. Clin Infect Dis 33:1713–1719PubMedCrossRefGoogle Scholar
  89. Mcjunkin JE, Khan R, De Los Reyes EC, Parsons DL, Minnich LL, Ashley RG, Tsai TF (1997) Treatment of severe La Crosse encephalitis with intravenous ribavirin following diagnosis by brain biopsy. Pediatrics 99:261–267PubMedCrossRefGoogle Scholar
  90. Mcjunkin JE, De Los Reyes EC, Irazuzta JE, Caceres MJ, Khan RR, Minnich LL, Fu KD, Lovett GD, Tsai T, Thompson A (2001) La Crosse encephalitis in children. N Engl J Med 344:801–807PubMedCrossRefGoogle Scholar
  91. Mclean RG, Ubico SR, Bourne D, Komar N (2002) West Nile virus in livestock and wildlife. Curr Top Microbiol Immunol 267:271–308PubMedGoogle Scholar
  92. Meegan JM (1979a) Rift Valley fever in Egypt: an overview of the epizootics in 1977 and 1978. Contrib Epidemiol Biostat 3:100–113Google Scholar
  93. Meegan JM (1979b) The Rift Valley fever epizootic in Egypt 1977-78. 1. Description of the epizzotic and virological studies. Trans R Soc Trop Med Hyg 73:618–623PubMedCrossRefGoogle Scholar
  94. Meegan JM, Watten RH, Laughlin LW (1979) Clinical experience with Rift Valley fever in humans during the 1977 Egyptian epizootic. Contrib Epidemiol Biostat 3:114–123Google Scholar
  95. Mishra MK, Basu A (2008) Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis. J Neurochem 105:1582–1595PubMedCrossRefGoogle Scholar
  96. Misra UK, Kalita J (2010) Overview: Japanese encephalitis. Prog Neurobiol 91:108–120PubMedCrossRefGoogle Scholar
  97. Miyake M (1964) The Pathology of Japanese Encephalitis. A Review. Bull World Health Organ 30:153–160PubMedGoogle Scholar
  98. Morens DM, Folkers GK, Fauci AS (2004) The challenge of emerging and re-emerging infectious diseases. Nature 430:242–249PubMedCrossRefGoogle Scholar
  99. Morrill JC, Mcclain DJ (1996) Epidemiology and pathogenesis of Rift Valley fever and other phleboviruses. In: Elliot R (ed) The Bunyaviridae. Plenum Press, New YorkGoogle Scholar
  100. Morrill JC, Peters CJ (2003) Pathogenicity and neurovirulence of a mutagen-attenuated Rift Valley fever vaccine in rhesus monkeys. Vaccine 21:2994–3002PubMedCrossRefGoogle Scholar
  101. Morrill JC, Jennings GB, Johnson AJ, Cosgriff TM, Gibbs PH, Peters CJ (1990) Pathogenesis of Rift Valley fever in rhesus monkeys: role of interferon response. Arch Virol 110:195–212PubMedCrossRefGoogle Scholar
  102. Morrill JC, Mebus CA, Peters CJ (1997a) Safety and efficacy of a mutagen-attenuated Rift Valley fever virus vaccine in cattle. Am J Vet Res 58:1104–1109PubMedGoogle Scholar
  103. Morrill JC, Mebus CA, Peters CJ (1997b) Safety of a mutagen-attenuated Rift Valley fever virus vaccine in fetal and neonatal bovids. Am J Vet Res 58:1110–1114PubMedGoogle Scholar
  104. Moutailler S, Krida G, Schaffner F, Vazeille M, Failloux AB (2008) Potential vectors of Rift Valley fever virus in the Mediterranean region. Vector Borne Zoonotic Dis 8:749–753PubMedCrossRefGoogle Scholar
  105. Murray KO, Mertens E, Despres P (2010) West Nile virus and its emergence in the United States of America. Vet Res 41:67CrossRefPubMedGoogle Scholar
  106. Ni H, Barrett AD (1996) Molecular differences between wild-type Japanese encephalitis virus strains of high and low mouse neuroinvasiveness. J Gen Virol 77(Pt 7):1449–1455PubMedCrossRefGoogle Scholar
  107. Ni H, Yun NE, Zacks MA, Weaver SC, Tesh RB, Da Rosa AP, Powers AM, Frolov I, Paessler S (2007) Recombinant alphaviruses are safe and useful serological diagnostic tools. Am J Trop Med Hyg 76:774–781PubMedGoogle Scholar
  108. Nichol ST, Arikawa J, Kawaoka Y (2000) Emerging viral diseases. PNAS 97:12411–12412CrossRefGoogle Scholar
  109. Nichol ST, Beaty BJ, Elliot RM, Al E (2005) Bunyaviridae. In: Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA (eds) Virus taxonomy eight report of the International Committee on Taxonomy of Viruses. Academic, AmsterdamGoogle Scholar
  110. Nimmannitya S, Halstead SB, Cohen SN, Margiotta MR (1969) Dengue and chikungunya virus infection in man in Thailand, 1962-1964. I. Observations on hospitalized patients with hemorrhagic fever. Am J Trop Med Hyg 18:954–971PubMedGoogle Scholar
  111. Padbidri VS, Gnaneswar TT (1979) Epidemiological investigations of chikungunya epidemic at Barsi, Maharashtra state, India. J Hyg Epidemiol Microbiol Immunol 23:445–451PubMedGoogle Scholar
  112. Paessler S, Fayzulin RZ, Anishchenko M, Greene IP, Weaver SC, Frolov I (2003) Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic. J Virol 77:9278–9286PubMedCrossRefGoogle Scholar
  113. Paessler S, Aguilar P, Anishchenko M, Wang HQ, Aronson J, Campbell G, Cararra AS, Weaver SC (2004) The hamster as an animal model for eastern equine encephalitis–and its use in studies of virus entrance into the brain. J Infect Dis 189:2072–2076PubMedCrossRefGoogle Scholar
  114. Paessler S, Ni H, Petrakova O, Fayzulin RZ, Yun N, Anishchenko M, Weaver SC, Frolov I (2006) Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses. J Virol 80:2784–2796PubMedCrossRefGoogle Scholar
  115. Patrican LA, Defoliart GR (1987) Aedes triseriatus and La Crosse virus: similar venereal infection rates in females given the first bloodmeal immediately before mating or several days after mating. Am J Trop Med Hyg 36:648–652PubMedGoogle Scholar
  116. Pekosz A, Phillips J, Pleasure D, Merry D, Gonzalez-Scarano F (1996) Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention. J Virol 70:5329–5335PubMedGoogle Scholar
  117. Peters CJ, Dalrymple JM (1990) Alphaviruses. In: Fields BN, Knipe DM, Chanok RM (eds) Virology, 2nd edn. Raven Press, New York, NYGoogle Scholar
  118. Petersen LR, Marfin AA (2002) West Nile virus: a primer for the clinician. Ann Intern Med 137:173–179PubMedGoogle Scholar
  119. Pialoux G, Gauzere BA, Jaureguiberry S, Strobel M (2007) Chikungunya, an epidemic arbovirosis. Lancet Infect Dis 7:319–327PubMedCrossRefGoogle Scholar
  120. Plassmeyer ML, Soldan SS, Stachelek KM, Roth SM, Martin-Garcia J, Gonzalez-Scarano F (2007) Mutagenesis of the La Crosse Virus glycoprotein supports a role for Gc (1066-1087) as the fusion peptide. Virology 358:273–282PubMedCrossRefGoogle Scholar
  121. Plyusnin A, Morzunov SP (2001) Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol 256:47–75PubMedGoogle Scholar
  122. Porterfield JS (1975) The basis of arbovirus classification. Med Biol 53:400–405PubMedGoogle Scholar
  123. Queyriaux B, Simon F, Grandadam M, Michel R, Tolou H, Boutin JP (2008) Clinical burden of chikungunya virus infection. Lancet Infect Dis 8:2–3PubMedCrossRefGoogle Scholar
  124. Randall R, Binn LN, Harrison VR (1964) Immunization against Rift Valley Fever Virus Studies on the Immunogenicity of Lyophilized Formalin-Inactivated Vaccine. J Immunol 93:293–299PubMedGoogle Scholar
  125. Reese SM, Beaty MK, Gabitzsch ES, Blair CD, Beaty BJ (2009) Aedes triseriatus females transovarially infected with La Crosse virus mate more efficiently than uninfected mosquitoes. J Med Entomol 46:1152–1158PubMedCrossRefGoogle Scholar
  126. Reisen W, Brault AC (2007) West Nile virus in North America: perspectives on epidemiology and intervention. Pest Manag Sci 63:641–646PubMedCrossRefGoogle Scholar
  127. Richardson-Burns SM, Tyler KL (2005) Minocycline delays disease onset and mortality in reovirus encephalitis. Exp Neurol 192:331–339PubMedCrossRefGoogle Scholar
  128. Richardson-Burns SM, Kominsky DJ, Tyler KL (2002) Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol 8:365–380PubMedCrossRefGoogle Scholar
  129. Rippy MK, Topper MJ, Mebus CA, Morrill JC (1992) Rift Valley fever virus-induced encephalomyelitis and hepatitis in calves. Vet Pathol 29:495–502PubMedCrossRefGoogle Scholar
  130. Rojanasuphot S, Charoensuk O, Kitprayura D, Likityingvara C, Limpisthien S, Boonyindee S, Jivariyavej V, Ugchusak K (1989) A field trial of Japanese encephalitis vaccine produced in Thailand. Southeast Asian J Trop Med Public Health 20:653–654PubMedGoogle Scholar
  131. Rust RS, Thompson WH, Matthews CG, Beaty BJ, Chun RW (1999) La Crosse and other forms of California encephalitis. J Child Neurol 14:1–14PubMedCrossRefGoogle Scholar
  132. Samuel MA, Diamond MS (2006) Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol 80:9349–9360PubMedCrossRefGoogle Scholar
  133. Schmaljohn CS, Hooper JW (2001) Bunyaviridae: the viruses and their replication. In: Howley DM (ed) Fields virology, 4th edn. Lippincott Williams and Wilkins, PhiladelphiaGoogle Scholar
  134. Schuffenecker I, Iteman I, Michault A, Murri S, Frangeul L, Vaney MC, Lavenir R, Pardigon N, Reynes JM, Pettinelli F, Biscornet L, Diancourt L, Michel S, Duquerroy S, Guigon G, Frenkiel MP, Brehin AC, Cubito N, Despres P, Kunst F, Rey FA, Zeller H, Brisse S (2006) Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Med 3:e263PubMedCrossRefGoogle Scholar
  135. Sejvar JJ, Haddad MB, Tierney BC, Campbell GL, Marfin AA, Van Gerpen JA, Fleischauer A, Leis AA, Stokic DS, Petersen LR (2003) Neurologic manifestations and outcome of West Nile virus infection. JAMA 290:511–515PubMedCrossRefGoogle Scholar
  136. Shrestha B, Gottlieb D, Diamond MS (2003) Infection and injury of neurons by West Nile encephalitis virus. J Virol 77:13203–13213PubMedCrossRefGoogle Scholar
  137. Sidwell RW, Smee DF (2003) Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control. Antiviral Res 57:101–111PubMedCrossRefGoogle Scholar
  138. Sitati EM, Diamond MS (2006) CD4+ T-cell responses are required for clearance of West Nile virus from the central nervous system. J Virol 80:12060–12069PubMedCrossRefGoogle Scholar
  139. Smithburn KC, Hughes TP, Burke AW, Paul JH (1940) A neurotropic virus isolated from the blood of a native of Uganda. Am J Trop Med 20:471–492Google Scholar
  140. Soldan SS, Gonzalez-Scarano F (2005) Emerging infectious diseases: the Bunyaviridae. J Neurovirol 11:412–423PubMedCrossRefGoogle Scholar
  141. Soldan SS, Hollidge BS, Wagner V, Weber F, Gonzalez-Scarano F (2010) La Crosse virus (LACV) Gc fusion peptide mutants have impaired growth and fusion phenotypes, but remain neurotoxic. Virology 404:139–147PubMedCrossRefGoogle Scholar
  142. Solomon T, Vaughn DW (2002) Pathogenesis and clinical features of Japanese encephalitis and West Nile virus infections. Curr Top Microbiol Immunol 267:171–194PubMedGoogle Scholar
  143. Solomon T, Kneen R, Dung NM, Khanh VC, Thuy TT, Ha DQ, Day NP, Nisalak A, Vaughn DW, White NJ (1998) Poliomyelitis-like illness due to Japanese encephalitis virus. Lancet 351:1094–1097PubMedCrossRefGoogle Scholar
  144. Solomon T, Dung NM, Kneen R, Gainsborough M, Vaughn DW, Khanh VT (2000) Japanese encephalitis. J Neurol Neurosurg Psychiatry 68:405–415PubMedCrossRefGoogle Scholar
  145. Stadler K, Allison SL, Schalich J, Heinz FX (1997) Proteolytic activation of tick-borne encephalitis virus by furin. J Virol 71:8475–8481PubMedGoogle Scholar
  146. Sucharit S, Surathin K, Shrestha SR (1989) Vectors of Japanese encephalitis virus (JEV): species complexes of the vectors. Southeast Asian J Trop Med Public Health 20:611–621PubMedGoogle Scholar
  147. Swanepoel R, Jaw C (2004) Rift Valley fever. In: Jaw C, Thompson GR, Tustin RD, Al E (eds) Infectious diseases of livestock with special reference to southern Africa, 2nd edn. Oxford University Press, Cape Town, South AfricaGoogle Scholar
  148. Thiboutot MM, Kannan S, Kawalekar OU, Shedlock DJ, Khan AS, Sarangan G, Srikanth P, Weiner DB, Muthumani K (2010) Chikungunya: a potentially emerging epidemic? PLoS Negl Trop Dis 4:623CrossRefGoogle Scholar
  149. Thomas D, Blakqori G, Wagner V, Banholzer M, Kessler N, Elliott RM, Haller O, Weber F (2004) Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist. J Biol Chem 279:31471–31477PubMedCrossRefGoogle Scholar
  150. Thompson W, Beaty BJ (1977) Venereal transmission of La Crosse (California encephalitis) arbovirus in Aedes triseriatus mosquitoes. Science 196:530–531PubMedCrossRefGoogle Scholar
  151. Thompson WH, Kalfayan B, Anslow RO (1965) Isolation of California Encephalitis Group Virus from a Fatal Human Illness. Am J Epidemiol 81:245–253PubMedGoogle Scholar
  152. Thompson BS, Moesker B, Smit JM, Wilschut J, Diamond MS, Fremont DH (2009) A therapeutic antibody against west nile virus neutralizes infection by blocking fusion within endosomes. PLoS Pathog 5:e1000453PubMedCrossRefGoogle Scholar
  153. Tournebize P, Charlin C, Lagrange M (2009) Neurological manifestations in Chikungunya: about 23 cases collected in Reunion Island. Rev Neurol (Paris) 165:48–51Google Scholar
  154. Trevejo RT, Eidson M (2008) Zoonosis update: West Nile virus. J Am Vet Med Assoc 232:1302–1309PubMedCrossRefGoogle Scholar
  155. Tsai TF (2000) New initiatives for the control of Japanese encephalitis by vaccination: minutes of a WHO/CVI meeting, Bangkok, Thailand, 13-15 October 1998. Vaccine 18(Suppl 2):1–25PubMedCrossRefGoogle Scholar
  156. van den Hurk AF, Ritchie SA, Mackenzie JS (2009) Ecology and geographical expansion of Japanese encephalitis virus. Annu Rev Entomol 54:17–35PubMedCrossRefGoogle Scholar
  157. Vogel P, Kell WM, Fritz DL, Parker MD, Schoepp RJ (2005) Early events in the pathogenesis of eastern equine encephalitis virus in mice. Am J Pathol 166:159–171PubMedGoogle Scholar
  158. Wang E, Petrakova O, Adams AP, Aguilar PV, Kang W, Paessler S, Volk SM, Frolov I, Weaver SC (2007) Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice. Vaccine 25:7573–7581PubMedCrossRefGoogle Scholar
  159. Watts D, Pantuwatana S, Defoliart GR, Yuill TM, Thompson WH (1973) Transovarial transmission of La Crosse virus (California encephalitis group) in the mosquito, Aedes triseriatus. Science 182:1140–1141PubMedCrossRefGoogle Scholar
  160. Watts DM, Thompson WH, Yuill TM, Defoliart GR, Hanson RP (1974) Overwintering of La Crosse virus in Aedes triseriatus. Am J Trop Med Hyg 23:694–700PubMedGoogle Scholar
  161. Weaver SC, Barrett AD (2004) Transmission cycles, host range, evolution and emergence of arboviral disease. Nat Rev Microbiol 2:789–801PubMedCrossRefGoogle Scholar
  162. Weaver SC, Reisen WK (2010) Present and future arboviral threats. Antiviral Res 85:328–345PubMedCrossRefGoogle Scholar
  163. Weaver SC, Powers AM, Brault AC, Barrett AD (1999) Molecular epidemiological studies of veterinary arboviral encephalitides. Vet J 157:123–138PubMedCrossRefGoogle Scholar
  164. WHO (2007) Outbreaks of Rift Valley fever in Kenya, Somalia, and United Republic of Tanzania, December 2006-April 2007. Wkly Epidemiol Rec 82:169–178Google Scholar
  165. WHO (2010a) Rift Valley fever.Google Scholar
  166. WHO (2010b) Rift Valley fever in South Africa.Google Scholar
  167. Wilson ML, Chapman LE, Hall DB, Dykstra EA, Ba K, Zeller HG, Traore-Lamizana M, Hervy JP, Linthicum KJ, Peters CJ (1994) Rift Valley fever in rural northern Senegal: human risk factors and potential vectors. Am J Trop Med Hyg 50:663–675PubMedGoogle Scholar
  168. Winter PM, Dung NM, Loan HT, Kneen R, Wills B, Thu Le T, House D, White NJ, Farrar JJ, Hart CA, Solomon T (2004) Proinflammatory cytokines and chemokines in humans with Japanese encephalitis. J Infect Dis 190:1618–1626PubMedCrossRefGoogle Scholar
  169. Yamanaka T, Tsujimura K, Kondo T, Yasuda W, Okada A, Noda K, Okumura T, Matsumura T (2006) Isolation and genetic analysis of Japanese encephalitis virus from a diseased horse in Japan. J Vet Med Sci 68:293–295PubMedCrossRefGoogle Scholar
  170. Yin J, Gardner CL, Burke CW, Ryman KD, Klimstra WB (2009) Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses. J Virol 83:10036–10047PubMedCrossRefGoogle Scholar
  171. Young DS, Kramer LD, Maffei JG, Dusek RJ, Backenson PB, Mores CN, Bernard KA, Ebel GD (2008) Molecular epidemiology of eastern equine encephalitis virus, New York. Emerg Infect Dis 14:454–460PubMedCrossRefGoogle Scholar
  172. Yu IM, Zhang W, Holdaway HA, Li L, Kostyuchenko VA, Chipman PR, Kuhn RJ, Rossmann MG, Chen J (2008) Structure of the immature dengue virus at low pH primes proteolytic maturation. Science 319:1834–1837PubMedCrossRefGoogle Scholar
  173. Zacks MA, Paessler S (2010) Encephalitic alphaviruses. Vet Microbiol 140:281–286PubMedCrossRefGoogle Scholar
  174. Zhang S, Li L, Woodson SE, Huang CY, Kinney RM, Barrett AD, Beasley DW (2006) A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus. Virology 353:35–40PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Bradley S. Hollidge
    • 1
    • 2
  • Francisco González-Scarano
    • 1
    • 3
  • Samantha S. Soldan
    • 1
    Email author
  1. 1.Department of NeurologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Neuroscience Graduate GroupUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of MicrobiologyUniversity of PennsylvaniaPhiladelphiaUSA

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