A Common Neuronal Response to Alphaherpesvirus Infection
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Alphaherpesviruses are a subfamily of the Herpesviridae that can invade the nervous system and establish either lytic or latent infections. The establishment of latent infection can occur only in neurons, indicating a unique virus–host interaction in these cells. Here, we compare results from seven microarray studies that focused on the host response of either neural tissue or isolated neurons to alphaherpesvirus infection. These studies utilized either herpes simplex virus type 1 or pseudorabies virus as the infectious agent. From these data, we have found common host responses spanning a variety of infection models in different species, with different herpesvirus strains, and during all phases of infection including lytic, latent, and reactivation. The repeated observation of transcriptional effects on these genes and gene families indicates their likely importance in host defenses or the viral infectious process. We discuss the possible role of these different genes and genes families in alphaherpesvirus infection.
Keywordsalphaherpesviruses HSV-1 virus latency microarray neurons gene expression
We thank C. Préhaud and M. Lafon for sharing additional data not shown in their prior publication. MLS is funded by the New Jersey Commission on Spinal Cord Research and NIH P40 RR 018604. OK is funded by Human Frontier Science Program. LE acknowledges support from NIH grants R37 NS 033506, R01 NS060699, P40 RR 018604, and P50 GM071508.
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