Journal of Neuroimmune Pharmacology

, Volume 2, Issue 3, pp 290–295

RanBPM, a Scaffolding Protein in the Immune and Nervous Systems

Invited Review

DOI: 10.1007/s11481-007-9079-x

Cite this article as:
Murrin, L.C. & Talbot, J.N. Jrnl Neuroimmune Pharm (2007) 2: 290. doi:10.1007/s11481-007-9079-x

Abstract

We review the literature for Ran Binding Protein in the Microtubule-Organizing Center (RanBPM; RanBP9), a 90-kDa protein that possesses many characteristics of a scaffolding protein, including protein-interaction motifs, a cytoskeletal-binding domain, and multiple canonical docking sites for signaling intermediates. We focus on studies that have examined functional interactions between RanBPM and other proteins. These studies suggest that RanBPM provides a platform for the interaction of a variety of signaling proteins, including cell surface receptors, nuclear receptors, nuclear transcription factors, and cytosolic kinases. These studies indicate that RanBPM acts as a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system.

Keywords

RanBPM RanBP9 scaffolding proteins SPRY domain LISH/CTLH domain signal transduction 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Department of Pharmacology and Experimental Neuroscience985800 Nebraska Medical CenterOmahaUSA
  2. 2.Department of Pharmaceutical and Biomedical SciencesRaabe College of Pharmacy, Ohio Northern UniversityAdaUSA

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