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Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells

  • Thomas W. KleinEmail author
  • Guy A. Cabral
Invited Review

Abstract

The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in the regulation of not only brain function but also the regulation of the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are suppressed by these agents leading to the hypothesis that these drugs may be of value in the management of chronic inflammatory diseases. In this report, we review current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs.

Keywords

Fatty Acid Amide Hydrolase Vanilloid Receptor Palmitoylethanolamide Ajulemic Acid Noladin Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported in part by DA03646 (TWK) and DA05832 and DA15608 (GAC) from NIDA.

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Copyright information

© Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Department of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA
  2. 2.Department of Microbiology and ImmunologyVirginia Commonwealth University, School of MedicineRichmondUSA

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