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Journal of Neuroimmune Pharmacology

, Volume 1, Issue 1, pp 32–40 | Cite as

Macrophage Colony-Stimulating Factor in the Pathogenesis of HIV Infection: Potential Target for Therapeutic Intervention

  • Valerie Haine
  • Tracy Fischer-Smith
  • Jay RappaportEmail author
Invited Review

Abstract

Macrophage colony stimulating factor (M-CSF) appears to play a major role in promoting and maintaining reservoirs of human immunodeficiency virus type 1 (HIV-1) in infected individuals. HIV-1 infection induces production of M-CSF by macrophages, which in turn promotes further infection of macrophages via increases in CD4 and CCR5 receptors, as well as increases in virus gene expression. M-CSF promotes the ontogeny and survival of macrophages, contributing to both the number and longevity of these infected cells. M-CSF dysregulation promotes the differentiation of monocytes toward macrophages and osteoclasts and at the same time may inhibit differentiation toward dendritic cells, resulting in immune impairment. The potential role of M-CSF in HIV-associated end organ diseases including HIV-associated dementia, HIV-associated nephropathy, and osteoporosis is discussed. This review emphasizes the need for developing M-CSF antagonists for treatment of HIV-1-infected patients.

Keywords

M-CSF CSF-1 HIV-1 Virus replication Nephropathy Osteoporosis 

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Copyright information

© Springer Science+Business Media 2006

Authors and Affiliations

  • Valerie Haine
    • 1
  • Tracy Fischer-Smith
    • 1
  • Jay Rappaport
    • 1
    Email author
  1. 1.Department of Neuroscience, Center for NeurovirologyTemple University School of MedicinePhiladelphiaUSA

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