Neurocognitive Impairment and Personality Traits in Alcohol Addiction: Effect of Dual Pathology

  • Yusel Iraklys Salazar-Guerra
  • Yunier Broche-Pérez
  • Amaray Cabrera Muñoz
  • Antonio Jesús Caballero-Moreno
  • Janet Perodín Hernández
  • Raul Mendoza-QuiñonesEmail author
Original Article


This study aimed to determine if patients with dual diagnosis (DD) are especially prone to have more clinical and neurocognitive deficits than addictive patients without psychiatric comorbidity. A cross-sectional study was designed to examine the clinical and neuropsychological profile of women with alcohol dependence (AD). The sample comprised of 178 AD patients and was divided into two groups defined by the presence versus absence of DD. DD-AD patients showed higher severity of the clinical pattern of alcohol consumption compared with AD patients. Increased risk of DD was associated with impaired subjective need for alcohol (RR 5.695, p = 0.004), higher tolerance (RR 4.860, p = 0.016) and higher frequency of alcohol drinking (RR 3.154, p = 0.010). DD-AD patients also showed greater deficits in inhibitory control and cognitive impulsivity. Co-occurring mental health and substance abuse disorders is a complex problem that deserves efforts to achieve optimum outcomes of care for this population.


Alcohol dependence Impulsivity Dual diagnosis 



The Cuban Center for Neurosciences and the Psychiatry Unit “Gali Garcia” supervised the design or conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript. The authors gratefully acknowledge the assistance of the women who participated in this study.

Funding Information

The Ministry of Science, Technology and Environment (CITMA, Spanish acronym) supported this research.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Yusel Iraklys Salazar-Guerra
    • 1
    • 5
  • Yunier Broche-Pérez
    • 2
  • Amaray Cabrera Muñoz
    • 3
  • Antonio Jesús Caballero-Moreno
    • 1
  • Janet Perodín Hernández
    • 4
  • Raul Mendoza-Quiñones
    • 4
    Email author
  1. 1.Unidad Psiquiátrica del Hospital General “Enrique Cabrera”HavanaCuba
  2. 2.Universidad Central “Marta Abreu” de Las VillasSanta ClaraCuba
  3. 3.Havana Psychiatric Hospital “Comandante Doctor Eduardo Bernabé Ordaz Ducunge”HavanaCuba
  4. 4.Department Biological PsychiatryCuban Center for NeurosciencesHavanaCuba
  5. 5.Universidad Laica EloyAlfaro de Manabí,MantaEcuador

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