Alcohol-Dependent Individuals Make Detrimental Decisions under Ambiguous and Perilous Conditions

  • Chengjuan Xie
  • Lili Yuan
  • Yu Meng
  • Kai Wang
Original Article


The present study assessed the decision-making abilities of patients with alcohol dependence (AD) under ambiguity or risk conditions. Forty-eight AD patients and 50 healthy controls (HC) were subjected to the Mini-Mental State Examination (MMSE), Iowa Gambling Task (IGT), and Game of Dice Task (GDT) systems for evaluating their decision-making ability. Age, duration of education, and MMSE scores were compared between the AD and HC groups. The communication in each block/choice and the group was evaluated along with the relationship between the trial block and choice. The basic characteristics were similar between both groups. Reduced mean net scores (IGT) and frequencies of choice were found for various alternatives (GDT) in AD patients as compared to the healthy controls. The net scores of first block (IGT test) and GDT test in AD patients were associated remarkably. These findings indicated a worse decision-making performance in AD patients compared to HCs under both ambiguity and risk conditions.


Alcohol Dependence Decision-making Disadvantageous choices Risk-taking 


Compliance with Ethical Standards

Ethical Approval

This study was approved by the Anhui Medical University Ethics Committee, and written informed consent was obtained from all participants, who voluntarily participated in the trial, with no financial compensation awarded for their performance.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare that they have no any conflict of interests.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Chengjuan Xie
    • 1
    • 2
    • 3
  • Lili Yuan
    • 1
    • 2
    • 3
  • Yu Meng
    • 1
    • 2
    • 3
  • Kai Wang
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of NeurologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiChina
  2. 2.Anhui Province Key Laboratory of Cognition and Neuropsychiatric DisordersHefeiChina
  3. 3.Collaborative Innovation Center for Neuropsychiatric Disorders and Mental HealthHefeiChina
  4. 4.Department of Medical PsychologyAnhui Medical UniversityHefeiChina

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