Solid and Hollow Gold Nanostructures for Nanomedicine: Comparison of Photothermal Properties
The photothermal properties of solid and hollow gold nanostructures represented by colloidal solutions of spherical nanoparticles, nanoshells, and nanocages upon irradiation with a 100 mW 808 nm continuous-wave laser for the first time were experimentally compared under identical optical density and nanoparticle concentration conditions. Accompanying computer modeling of light absorption by the studied gold nanostructures revealed the general parameters influencing the photothermal efficiency, which is of significance for nanomedical applications. The spectral position of localized plasmonic excitations of the studied nanostructures ranged from 518 nm for solid gold nanoparticles to 718 nm for gold nanocages, which provided a possibility to observe a direct influence of the wavelength proximity between the localized surface plasmon resonance and laser line on the heat generation capability of the nanostructures. As a result, the best photothermal efficiency was registered for gold nanocages, which proves them as an efficient photothermal treatment agent and a possible candidate to build a nanocarrier platform for drug delivery with a controlled release. Light absorption modeling demonstrated an existence of optimal wall thickness for gold nanoshells that should lead to the maximum photothermal efficiency when irradiated with 808 nm light, which varied from about 0.1 to 0.4 in units of external nanoshell radius with an increase of the wall porosity. Additionally, computer modeling results show that increased wall porosity should lead to enhanced photothermal efficiency of polydisperse colloidal solutions of hollow gold nanostructures.
KeywordsLocalized surface plasmon resonance Gold nanoparticles Gold nanoshells Gold nanocages Photothermal plasmonic effect Nanocarrier
The authors are very thankful for the financial support from Science and Technology Center in Ukraine (project N 6044; 2015-2017). We are deeply indebted to Prof. V. P. Kladko of V. E. Lashkaryov Institute of Semiconductor Physics of National Academy of Sciences of Ukraine for performing XRD measurements and Dr. D. O. Klymchuk of M. G. Kholodny Institute of Botany of National Academy of Sciences of Ukraine for performing TEM measurements.
This study was funded by Science and Technology Center in Ukraine (grant number 6044).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
- 7.Yao C, Zhang L, Wang J, He Y, Xin J, Wang S et al (2016) Gold nanoparticle mediated phototherapy for cancer. J Nanomater 2016:5497136Google Scholar
- 12.Guo L, Li Y, Xiao Z, Lu W (2014) Photothermal properties of hollow gold nanostructures for cancer theranostics. In: Bhushan B, Luo D, Schricker SR, Sigmund W, Zauscher S (eds) Handbook of nanomaterials properties. Springer-Verlag, Berlin Heidelberg, pp 1199–1226. https://doi.org/10.1007/978-3-642-31107-9_50 CrossRefGoogle Scholar
- 16.Jain PK, Lee KS, El-Sayed IH, El-Sayed MA (2006) Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 110(14):7238–7248. https://doi.org/10.1021/jp057170o CrossRefPubMedGoogle Scholar
- 20.Zhang G, Yang Z, Lu W, Zhang R, Huang Q, Tian M, Li L, Liang D, Li C (2009) Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials 30(10):1928–1936. https://doi.org/10.1016/j.biomaterials.2008.12.038 CrossRefPubMedPubMedCentralGoogle Scholar
- 22.Sharma P, Brown SC, Singh A, Iwakuma N, Pyrgiotakis G, Krishna V, Knapik JA, Barr K, Moudgil BM, Grobmyer SR (2010) Near-infrared absorbing and luminescent gold speckled silica nanoparticles for photothermal therapy. J Mater Chem 20(25):5182–5185. https://doi.org/10.1039/c0jm00354a CrossRefGoogle Scholar
- 23.Ayala-Orozco C, Urban C, Knight MW, Urban AS, Neumann O, Bishnoi SW, Mukherjee S, Goodman AM, Charron H, Mitchell T, Shea M, Roy R, Nanda S, Schiff R, Halas NJ, Joshi A (2014) Au nanomatryoshkas as efficient near-infrared photothermal transducers for cancer treatment: benchmarking against nanoshells. ACS Nano 8(6):6372–6381. https://doi.org/10.1021/nn501871d CrossRefPubMedPubMedCentralGoogle Scholar
- 25.Wang Y, Black KCL, Luehmann H, Li W, Zhang Y, Cai X, Wan D, Liu SY, Li M, Kim P, Li ZY, Wang LV, Liu Y, Xia Y (2013) Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. ACS Nano 7(3):2068–2077. https://doi.org/10.1021/nn304332s CrossRefPubMedPubMedCentralGoogle Scholar
- 38.Hembury M, Chiappini C, Bertazzo S, Kalber TL, Drisko GL, Ogunlade O, Walker-Samuel S, Krishna KS, Jumeaux C, Beard P, Kumar CSSR, Porter AE, Lythgoe MF, Boissière C, Sanchez C, Stevens MM (2015) Gold–silica quantum rattles for multimodal imaging and therapy. Proc Natl Acad Sci U S A 112(7):1959–1964. https://doi.org/10.1073/pnas.1419622112 CrossRefPubMedPubMedCentralGoogle Scholar